Current HIV/AIDS Reports

, Volume 9, Issue 1, pp 44–51

Human Microbiome and HIV/AIDS

  • Deepak Saxena
  • Yihong Li
  • Liying Yang
  • Zhiheng Pei
  • Michael Poles
  • William R. Abrams
  • Daniel Malamud
The Science of HIV (AL Landay, Section Editor)

DOI: 10.1007/s11904-011-0103-7

Cite this article as:
Saxena, D., Li, Y., Yang, L. et al. Curr HIV/AIDS Rep (2012) 9: 44. doi:10.1007/s11904-011-0103-7

Abstract

Understanding of the human microbiome continues to grow rapidly; however, reports on changes in the microbiome after HIV infection are still limited. This review surveys the progress made in methodology associated with microbiome studies and highlights the remaining challenges to this field. Studies have shown that commensal oral, gut, vaginal, and penile bacteria are vital to the health of the human immune system. Our studies on crosstalk among oral and gastrointestinal soluble innate factors, HIV, and microbes indicated that the oral and gut microbiome was altered in the HIV-positive samples compared to the negative controls. The importance of understanding the bacterial component of HIV/AIDS, and likelihood of “crosstalk” between viral and bacterial pathogens, will help in understanding the role of the microbiome in HIV-infected individuals and facilitate identification of novel antiretroviral factors for use as novel diagnostics, microbicides, or therapeutics against HIV infection.

Keywords

HIVOral microbiomeOral manifestationInnate immunity454 pyrosequencingGut microbiomeHighly Active Antiretroviral TherapyCrosstalk

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Deepak Saxena
    • 1
  • Yihong Li
    • 1
  • Liying Yang
    • 2
  • Zhiheng Pei
    • 2
  • Michael Poles
    • 3
  • William R. Abrams
    • 1
  • Daniel Malamud
    • 1
  1. 1.Department of Basic Science and Craniofacial BiologyNew York University College of DentistryNew YorkUSA
  2. 2.Department of PathologyNew York University Langone Medical CenterNew YorkUSA
  3. 3.Departments of MedicineNew York University Langone Medical CenterNew YorkUSA