Simard EP, Engels EA. Cancer as a cause of death among people with AIDS in the United States. Clin Infect Dis. 2010;51:957–62.PubMedCrossRefGoogle Scholar
Lewden C, May T, Rosenthal E, et al. Changes in causes of death among adults infected by HIV between 2000 and 2005: The "Mortalite 2000 and 2005" surveys (ANRS EN19 and Mortavic). J Acquir Immune Defic Syndr. 2008;48:590–8.PubMedCrossRefGoogle Scholar
Phillips AA, Justman JE. Screening HIV-infected patients for non-AIDS-defining malignancies. Curr HIV/AIDS Rep. 2009;6:83–92.PubMedCrossRefGoogle Scholar
Croswell JM, Ransohoff DF, Kramer BS. Principles of cancer screening: lessons from history and study design issues. Semin Oncol. 2010;37:202–15.PubMedCrossRefGoogle Scholar
• Braithwaite RS, Fiellin D, Justice AC: The payoff time: a flexible framework to help clinicians decide when patients with comorbid disease are not likely to benefit from practice guidelines. Med Care 2009;47:610-7. This article describes "payoff time," a conceptual approach to tailoring cancer screening guidelines to patients with significant comorbid illness.
Justice AC. Prioritizing primary care in HIV: comorbidity, toxicity, and demography. Top HIV Med. 2006;14:159–63.PubMedGoogle Scholar
• Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet 2008;372:293-9. This analysis provides information on life expectancy in HIV patients on cART depending on age and CD4 count at treatment initiation.
Losina E, Schackman BR, Sadownik SN, et al. Racial and sex disparities in life expectancy losses among HIV-infected persons in the united states: impact of risk behavior, late initiation, and early discontinuation of antiretroviral therapy. Clin Infect Dis. 2009;49:1570–8.PubMedCrossRefGoogle Scholar
Harrison KM, Song R, Zhang X. Life expectancy after HIV diagnosis based on national HIV surveillance data from 25 states, United States. J Acquir Immune Defic Syndr. 2010;53:124–30.PubMedCrossRefGoogle Scholar
Green TC, Kershaw T, Lin H, et al. Patterns of drug use and abuse among aging adults with and without HIV: a latent class analysis of a US Veteran cohort. Drug Alcohol Depend. 2010;110:208–20.PubMedCrossRefGoogle Scholar
May M, Sterne JA, Sabin C, et al. Prognosis of HIV-1-infected patients up to 5 years after initiation of HAART: collaborative analysis of prospective studies. AIDS. 2007;21:1185–97.PubMedCrossRefGoogle Scholar
Lewden C, Chene G, Morlat P, et al. HIV-infected adults with a CD4 cell count greater than 500 cells/mm3 on long-term combination antiretroviral therapy reach same mortality rates as the general population. J Acquir Immune Defic Syndr. 2007;46:72–7.PubMedCrossRefGoogle Scholar
• Justice AC, McGinnis KA, Skanderson M, et al.: Towards a combined prognostic index for survival in HIV infection: the role of 'non-HIV' biomarkers. HIV Med 2010;11:143-51. This article describes the derivation and validation of a prognostic index strongly correlated with survival for HIV-infected patients utilizing both HIV-specific and non–HIV-related biomarkers.
Justice A, Modur S, Tate J, al. e: A Prognostic Index for those Aging with HIV: Extension of the VACS Index to those on Combination Anti-Retroviral Therapy (cART) [abstract #793]. Presented at the 18th Conference on Retroviruses and Opportunistic Infections; Boston, MA: 2011.
Brown ST, Kyriakides T, Kirkwood K, et al.: The VACS Risk Index responds to treatment interventions and is highly correlated with and previctive of mortality events in the OPTIMA study [Poster 16436]. Presented at the 14th International Workshop on HIV Observational Databases: 2010.
Engels EA, Biggar RJ, Hall HI, et al. Cancer risk in people infected with human immunodeficiency virus in the United States. Int J Cancer. 2008;123:187–94.PubMedCrossRefGoogle Scholar
Seaberg EC, Wiley D, Martinez-Maza O, et al. Cancer incidence in the multicenter aids cohort study before and during the HAART era: 1984 to 2007. Cancer. 2010;116:5507–16.PubMedCrossRefGoogle Scholar
•• Bedimo RJ, McGinnis KA, Dunlap M, et al.: Incidence of non-AIDS-defining malignancies in HIV-infected versus noninfected patients in the HAART era: impact of immunosuppression. J Acquir Immune Defic Syndr. 2009;52:203-8. This article provides excellent estimates of cART era NADC risk and incidence rates using data from a large US HIV cohort.
Silverberg MJ, Abrams DI. AIDS-defining and non-AIDS-defining malignancies: cancer occurrence in the antiretroviral therapy era. Curr Opin Oncol. 2007;19:446–51.PubMedGoogle Scholar
•• Silverberg MJ, Chao C, Leyden WA, et al.: HIV infection and the risk of cancers with and without a known infectious cause. AIDS 2009;23:2337-45. This study provides excellent estimates of cART era NADC risk and incidence rates using data from a large US HIV cohort.
Recommendations of the United States Preventive Services Task Force. Available at Available at http://www.uspreventiveservicestaskforce.org
. Accessed Accessed March 2011.
Smith RA, Cokkinides V, Brooks D, et al. Cancer screening in the United States, 2010: a review of current American Cancer Society guidelines and issues in cancer screening. CA Cancer J Clin. 2010;60:99–119.PubMedCrossRefGoogle Scholar
• Chaturvedi AK, Madeleine MM, Biggar RJ, Engels EA: Risk of human papillomavirus-associated cancers among persons with AIDS. J Natl Cancer Inst. 2009;101:1120-30. This article describes the results of a large registry linkage study of HPV-related cancer incidence (1980–2004) in persons with AIDS.
1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Recomm Rep. 1993;41:1-19.
Serraino D, Carrieri P, Pradier C, et al. Risk of invasive cervical cancer among women with, or at risk for, HIV infection. Int J Cancer. 1999;82:334–7.PubMedCrossRefGoogle Scholar
Frisch M, Biggar RJ, Engels EA, Goedert JJ. Association of cancer with AIDS-related immunosuppression in adults. JAMA. 2001;285:1736–45.PubMedCrossRefGoogle Scholar
• Massad LS, Seaberg EC, Watts DH, et al.: Long-term incidence of cervical cancer in women with human immunodeficiency virus. Cancer 2009;115:524-30. This article describes cervical cancer rates in HIV-infected and uninfected participants in the WIHS study, finding no increased risk in the HIV-infected participants.
Minkoff H, Zhong Y, Burk RD, et al. Influence of adherent and effective antiretroviral therapy use on human papillomavirus infection and squamous intraepithelial lesions in human immunodeficiency virus-positive women. J Infect Dis. 2010;201:681–90.PubMedCrossRefGoogle Scholar
Screening for squamous cervical cancer: duration of low risk after negative results of cervical cytology and its implication for screening policies. IARC Working Group on evaluation of cervical cancer screening programmes. Br Med J (Clin Res Ed) 1986;293:659-64.Google Scholar
Kitchener H, Nelson L, Adams J, et al. Colposcopy is not necessary to assess the risk to the cervix in HIV-positive women: an international cohort study of cervical pathology in HIV-1 positive women. Int J Cancer. 2007;121:2484–91.PubMedCrossRefGoogle Scholar
McCredie MR, Sharples KJ, Paul C, et al. Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study. Lancet Oncol. 2008;9:425–34.PubMedCrossRefGoogle Scholar
Ries LA KC, Hankey BF, Miller BA. (Ed): SEER cancer statistics review, 1973–1996: tables and graphs: M.N.C.I.N.P.N.; 1999.
Recommendations of the United States Preventive Services Task Force: Cervical cancer screening. Available at http://www.uspreventiveservicestaskforce.org
. Accessed March 2011
Clifford GM, Smith JS, Plummer M, et al. Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis. Br J Cancer. 2003;88:63–73.PubMedCrossRefGoogle Scholar
AIDS Institute of New York State Guidelines: Neoplastic complications of HIV: Cervical Cancer. Available at http://www.hivguidelines.org/clinical-guidelines/adults/neoplastic-complications-of-hiv-infection/
. Accessed March 2011.
Harris TG, Burk RD, Palefsky JM, et al. Incidence of cervical squamous intraepithelial lesions associated with HIV serostatus, CD4 cell counts, and human papillomavirus test results. JAMA. 2005;293:1471–6.PubMedCrossRefGoogle Scholar
• Shiels MS, Cole SR, Kirk GD, Poole C: A meta-analysis of the incidence of non-AIDS cancers in HIV-infected individuals. J Acquir Immune Defic Syndr. 2009;52:611-22. This article describes the results of a large registry linkage study of age at cancer diagnosis in persons with AIDS, finding younger ages at presentation with lung cancer and anal cancer, and similar ages to the general population at presentation for other cancers.
Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM. Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet. 2007;370:59–67.PubMedCrossRefGoogle Scholar
Silverberg MJ, Lau B, Y J, et al.: Risk of anal cancer in HIV-infected patients and HIV-uninfected controls in North America. Presented at the 12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies; Bethesda, MD: April 2010.
Piketty C, Selinger-Leneman H, Grabar S, et al. Marked increase in the incidence of invasive anal cancer among HIV-infected patients despite treatment with combination antiretroviral therapy. AIDS. 2008;22:1203–11.PubMedCrossRefGoogle Scholar
D'Souza G, Wiley DJ, Li X, et al. Incidence and epidemiology of anal cancer in the multicenter AIDS cohort study. J Acquir Immune Defic Syndr. 2008;48:491–9.PubMedCrossRefGoogle Scholar
Frisch M, Fenger C, van den Brule AJ, et al. Variants of squamous cell carcinoma of the anal canal and perianal skin and their relation to human papillomaviruses. Cancer Res. 1999;59:753–7.PubMedGoogle Scholar
Hoots BE, Palefsky JM, Pimenta JM, Smith JS. Human papillomavirus type distribution in anal cancer and anal intraepithelial lesions. Int J Cancer. 2009;124:2375–83.PubMedCrossRefGoogle Scholar
Guiguet M, Boue F, Cadranel J, et al. Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study. Lancet Oncol. 2009;10:1152–9.PubMedCrossRefGoogle Scholar
de Pokomandy A, Rouleau D, Ghattas G, et al.: HAART and Progression to High-Grade Anal Intraepithelial Neoplasia in Men Who Have Sex with Men and Are Infected with HIV. Clin Infect Dis. 2011, Epub ahead of print.
Watson AJ, Smith BB, Whitehead MR, et al. Malignant progression of anal intra-epithelial neoplasia. ANZ J Surg. 2006;76:715–7.PubMedCrossRefGoogle Scholar
• Kreuter A, Potthoff A, Brockmeyer NH, et al.: Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany. Br J Dermatol. 2010;162:1269-77. This is a prospective study of HIV-infected MSM screened for anal cancer with anal cytology and subsequent HRA when indicated. It provides an estimate of rates of AIN and the correlation of these findings with cytology and HPV testing, as well as an estimate of the progression time of AIN to invasive cancer.
Darragh TM, Winkler B. Anal cancer and cervical cancer screening: Key differences. Cancer Cytopathol. 2011;119:5–19.PubMedCrossRefGoogle Scholar
Berry JM, Palefsky JM, Jay N, et al. Performance characteristics of anal cytology and human papillomavirus testing in patients with high-resolution anoscopy-guided biopsy of high-grade anal intraepithelial neoplasia. Dis Colon Rectum. 2009;52:239–47.PubMedCrossRefGoogle Scholar
• Lam JM, Hoch JS, Tinmouth J, et al.: Cost-effectiveness of screening for anal precancers in HIV-positive men. AIDS 2011;25:635-642. This article describes a cost-effectiveness analysis using data from a cross-sectional study of HIV-infected MSM who received concurrent screening with anal cytology, HRA, and HPV testing, finding HRA to be the most cost-effective modality.Google Scholar
Salit IE, Lytwyn A, Raboud J, et al. The role of cytology (Pap tests) and human papillomavirus testing in anal cancer screening. AIDS. 2010;24:1307–13.PubMedGoogle Scholar
Park IU, Palefsky JM. Evaluation and Management of Anal Intraepithelial Neoplasia in HIV-Negative and HIV-Positive Men Who Have Sex with Men. Curr Infect Dis Rep. 2010;12:126–33.PubMedCrossRefGoogle Scholar
Fox PA, Nathan M, Francis N, et al. A double-blind, randomized controlled trial of the use of imiquimod cream for the treatment of anal canal high-grade anal intraepithelial neoplasia in HIV-positive MSM on HAART, with long-term follow-up data including the use of open-label imiquimod. AIDS. 2010;24:2331–5.PubMedCrossRefGoogle Scholar
Surveillance, Epidemiology and End Results Cancer Stat Fact Sheets. Available at http://seer.cancer.gov/statfacts/html/anus.html
. Accessed Accessed March 15, 2011
Tinmouth J, Raboud J, Ali M, et al.: The psychological impact of being screened for anal cancer in HIV-infected men who have sex with men. Dis Colon Rectum. 54:352-9.
Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277–300.PubMedCrossRefGoogle Scholar
Goedert JJ, Cote TR, Virgo P, et al. Spectrum of AIDS-associated malignant disorders. Lancet. 1998;351:1833–9.PubMedCrossRefGoogle Scholar
Goedert JJ, Schairer C, McNeel TS, et al. Risk of breast, ovary, and uterine corpus cancers among 85,268 women with AIDS. Br J Cancer. 2006;95:642–8.PubMedCrossRefGoogle Scholar
Hessol NA, Napolitano LA, Smith D, et al. HIV tropism and decreased risk of breast cancer. PLoS One. 2010;5:e14349.PubMedCrossRefGoogle Scholar
Recommendations of the United States Preventive Services Task Force: Breast Cancer Screening. Available at Available at http://www.uspreventiveservicestaskforce.org
. Accessed Accessed March 2011
Nelson HD, Tyne K, Naik A, et al.: Screening for breast cancer: an update for the U.S. Preventive Services Task Force. Ann Intern Med. 2009;151:727-737, W237-742.Google Scholar
• Kothari ND, Engelson ES, Drake V, et al.: Effect of HIV infection on the prevalence of colorectal adenomas during screening colonoscopy. J Clin Gastroenterol. 2010;44:77-8. This is a cross sectional study of a large group of HIV-infected and uninfected patients undergoing colonoscopy; no difference in rates of adenomas was observed in either group.
Henley SJ, King JB, German RR, et al. Surveillance of screening-detected cancers (colon and rectum, breast, and cervix) - United States, 2004-2006. MMWR Surveill Summ. 2010;59:1–25.PubMedGoogle Scholar
• Atkin WS, Edwards R, Kralj-Hans I, et al.: Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial. Lancet 2010;375:1624-33. This is a recently published RCT showing a mortality benefit associated with colorectal cancer screening by sigmoidoscopy.
AIDS Institute of New York State Guidelines: Neoplastic complications of HIV - Colorectal cancer screening. Available at http://www.hivguidelines.org/clinical-guidelines/adults/neoplastic-complications-of-hiv-infection/
. Accessed March 2011
• Shiels MS, Goedert JJ, Moore RD, et al.: Reduced risk of prostate cancer in U.S. Men with AIDS. Cancer Epidemiol Biomarkers Prev. 2010;19:2910-5. This article estimates prostate cancer risk in men with AIDS in a large registry-linkage study, as well as PSA testing rates from a clinical cohort, finding a decreased risk of prostate cancer in men with AIDS as well as low PSA testing rates.
Silverberg MJ, Klein D, Leyden WA, et al.: Prostate cancer risk and use of prostate specific antigen tests among HIV-infected and HIV-uninfected men [abstract#1097]. Presented at the 48th Infectious Disease Society of America Annual Meeting; Vancouver, Canada: October 2010.
Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2008;149:185-91.Google Scholar
•• Andriole GL, Crawford ED, Grubb RL, 3rd, et al.: Mortality results from a randomized prostate-cancer screening trial. N Engl J Med. 2009;360:1310-9. This article describes the initial results of a large RCT of prostate cancer screening, finding no mortality difference among screened and unscreened patients.
•• Schroder FH, Hugosson J, Roobol MJ, et al.: Screening and prostate-cancer mortality in a randomized European study. N Engl J Med. 2009;360:1320-8. These are the results of a large RCT of prostate cancer screening, finding a small mortality benefit with screening at the cost of significant overtreatment.
Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology. 2005;42:1208–36.PubMedCrossRefGoogle Scholar
Brau N, Fox RK, Xiao P, et al. Presentation and outcome of hepatocellular carcinoma in HIV-infected patients: a U.S.-Canadian multicenter study. J Hepatol. 2007;47:527–37.PubMedCrossRefGoogle Scholar
Zhang BH, Yang BH, Tang ZY. Randomized controlled trial of screening for hepatocellular carcinoma. J Cancer Res Clin Oncol. 2004;130:417–22.PubMedGoogle Scholar
Forner A, Reig M, Bruix J. Alpha-fetoprotein for hepatocellular carcinoma diagnosis: the demise of a brilliant star. Gastroenterology. 2009;137:26–9.PubMedCrossRefGoogle Scholar
Vibert E, Duclos-Vallee JC, Ghigna MR, et al.: Liver transplantation for hepatocellular carcinoma: The impact of human immunodeficiency virus infection. Hepatology 2011, Epub ahead of print.
Sigel K, Wisnivesky J, Justice AC, et al.: HIV is an Independent Risk Factor for Lung Cancer Incidence [abstract#30]. Presented at the 17th Conference on Retroviruses and Opportunistic Infections; San Francisco, CA: 2010.
Shiels MS, Cole SR, Mehta SH, Kirk GD. Lung cancer incidence and mortality among HIV-infected and HIV-uninfected injection drug users. J Acquir Immune Defic Syndr. 2010;55:510–5.PubMedCrossRefGoogle Scholar
Ries LAG YJ, Keel GE, Eisner MP, Lin YD, Horner M-J (Ed): SEER Survival Monograph: Cancer Survival Among Adults: U.S. SEER Program, 1988-2001, Patient and Tumor Characteristics.: National Cancer Institute, SEER Program, NIH Pub. No. 07-6215, Bethesda, MD; 2007.
Crothers K, Goulet JL, Rodriguez-Barradas MC, et al. Impact of cigarette smoking on mortality in HIV-positive and HIV-negative veterans. AIDS Educ Prev. 2009;21:40–53.PubMedCrossRefGoogle Scholar
Henschke CI, Naidich DP, Yankelevitz DF, et al. Early lung cancer action project: initial findings on repeat screenings. Cancer. 2001;92:153–9.PubMedCrossRefGoogle Scholar
National Lung Screening Trial (NLST) Initial Results. Available at http://www.cancer.gov/newscenter/pressreleases/NLSTFastFacts
. Accessed 2010