WHO, UNAIDS: AIDS epidemic update: December 2009. UNAIDS: Geneva, Switzerland; 2009.
Vermund SH: Rationale for the testing and use of a partially effective HIV vaccine. AIDS Res Hum Retroviruses 1998, 14(Suppl 3):S321–S323.PubMed
Vergidis PI, Falagas ME: Meta-analyses on behavioral interventions to reduce the risk of transmission of HIV. Infect Dis Clin North Am 2009, 23:309–314.CrossRefPubMed
Johnson WD, et al.: Behavioral interventions to reduce risk for sexual transmission of HIV among men who have sex with men. Cochrane Database Syst Rev 2008, CD001230.
Herbst JH, et al.: A meta-analytic review of HIV behavioral interventions for reducing sexual risk behavior of men who have sex with men. J Acquir Immune Defic Syndr 2005, 39:228–241.PubMed
Crepaz N, Marshall KJ, Aupont LW, et al.: The efficacy of HIV/STI behavioral interventions for African American females in the United States: a meta-analysis. Am J Public Health 2009, 99:2069–2078.CrossRefPubMed
Noar SM, Black HG, Pierce LB: Efficacy of computer technology-based HIV prevention interventions: a meta-analysis. AIDS 2009, 23:107–115.CrossRefPubMed
Crepaz N, Horn AK, Rama SM, et al.: The efficacy of behavioral interventions in reducing HIV risk sex behaviors and incident sexually transmitted disease in black and Hispanic sexually transmitted disease clinic patients in the United States: a meta-analytic review. Sex Transm Dis 2007, 34:319–332.PubMed
Vergidis PI, Falagas ME, Hamer DH: Meta-analytical studies on the epidemiology, prevention, and treatment of human immunodeficiency virus infection. Infect Dis Clin North Am 2009, 23:295–308.CrossRefPubMed
Sturt AS, Dokubo EK, Sint TT: Antiretroviral therapy (ART) for treating HIV infection in ART-eligible pregnant women. Cochrane Database Syst Rev 2010, 3:CD008440.
Siegfried N, et al.: Male circumcision for prevention of heterosexual acquisition of HIV in men. Cochrane Database Syst Rev 2009, 2:CD003362.
Chigwedere P, Seage GR, Lee TH, Essex M: Efficacy of antiretroviral drugs in reducing mother-to-child transmission of HIV in Africa: a meta-analysis of published clinical trials. AIDS Res Hum Retroviruses 2008, 24:827–837.CrossRefPubMed
Denison JA, O’Reilly KR, Schmid GP, et al.: HIV voluntary counseling and testing and behavioral risk reduction in developing countries: a meta-analysis, 1990–2005. AIDS Behav 2008, 12:363–373.CrossRefPubMed
Modjarrad K, Vermund SH: Effect of treating co-infections on HIV-1 viral load: a systematic review. Lancet Infect Dis 2010, 10:455–463.CrossRefPubMed
Gowing L, et al.: Substitution treatment of injecting opioid users for prevention of HIV infection. Cochrane Database Syst Rev 2008, 2:CD004145.
Buvé A: Track C Epidemiology and Prevention Sciences Rapporteur Summary. In XVIII International AIDS Conference. Vienna: IAS; 2010.
Padian NS, McCoy SI, Balkus JE, Wasserheit JN: Weighing the gold in the gold standard: challenges in HIV prevention research. AIDS 2010, 24:621–635.CrossRefPubMed
•• Piot P, Bartos M, Larson H, et al.: Coming to terms with complexity: a call to action for HIV prevention. Lancet 2008, 372:845–859. This is a clarion call to utilize the available science and to mobilize an HIV prevention constituency that engages affected communities
Holtgrave DR: Is the elimination of HIV infection within reach in the United States? Lessons from an epidemiologic transmission model. Public Health Rep 2010, 125:372–376.PubMed
UNAIDS Prevention Reference Group definition. From UNAIDS Taxonomy of HIV Prevention Activities. Discussion draft for UNAIDS HIV Prevention Reference Group meeting. March 2–4, 2009.
Wingood GM, DiClemente RJ: The ADAPT-ITT model: a novel method of adapting evidence-based HIV interventions. J Acquir Immune Defic Syndr 2008, 47(Suppl 1):S40–S46.PubMed
Glasgow RE, Vogt TM, Boles SM: Evaluating the public health impact of health promotion interventions: the RE-AIM framework. Am J Public Health 1999, 89:1322–1327.CrossRefPubMed
Methods for Prevention Packages Program (MP3 II) (R01) Available at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-10-005.html
. Accessed August 2010.
Wilson D, Halperin DT: “Know your epidemic, know your response”: a useful approach, if we get it right. Lancet 2008, 372:423–426.CrossRefPubMed
Vandenbruaene M: King Kennard Holmes—chair of the Department of Global Health of The University of Washington. Interviewed by Marc Vandenbruaene. Lancet Infect Dis 2007, 7:516–520.CrossRef
Stoneburner RL, Low-Beer D: Sexual partner reductions explain human immunodeficiency virus declines in Uganda: comparative analyses of HIV and behavioural data in Uganda, Kenya, Malawi, and Zambia. Int J Epidemiol 2004, 33:624.CrossRefPubMed
Blower SM, Gershengorn HB, Grant RM: A tale of two futures: HIV and antiretroviral therapy in San Francisco. Science 2000, 287:650–654.CrossRefPubMed
•• Granich RM, Gilks CF, Dye C, et al.: Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet 2009, 373:48–57. This modeling exercise ignited debate regarding what might be possible for epidemic control if universal HIV testing, treatment, and adherence support were fully accessible
Dodd PJ, Garnett GP, Hallett TB: Examining the promise of HIV elimination by ‘test and treat’ in hyperendemic settings. AIDS 2010, 24:729–735.CrossRefPubMed
Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, et al.: Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med 2009, 361:2209–2220.CrossRefPubMed
Korenromp EL, White RG, Orroth KK, et al.: Determinants of the impact of sexually transmitted infection treatment on prevention of HIV infection: a synthesis of evidence from the Mwanza, Rakai, and Masaka intervention trials. J Infect Dis 2005, 191(Suppl 1):S168–S178.CrossRefPubMed
Allen S, Tice J, Van de Perre P, et al.: Effect of serotesting with counselling on condom use and seroconversion among HIV discordant couples in Africa. BMJ 1992, 304:1605–1609.CrossRefPubMed
Bunnell R, Cherutich P: Universal HIV testing and counselling in Africa. Lancet 2008, 371:2148–2150.CrossRefPubMed
Celum CL, Robinson NJ, Cohen MS: Potential effect of HIV type 1 antiretroviral and herpes simplex virus type 2 antiviral therapy on transmission and acquisition of HIV type 1 infection. J Infect Dis 2005, 191(Suppl 1):S107–S114.CrossRefPubMed
Bassett IV: Integrating HIV screening into routine health care in resource-limited settings. Clin Infect Dis 2010, 50(Suppl 3):S77–S84.CrossRefPubMed
Khumalo-Sakutukwa G, et al.: Project Accept (HPTN 043): a community-based intervention to reduce HIV incidence in populations at risk for HIV in sub-Saharan Africa and Thailand. J Acquir Immune Defic Syndr 2008, 49:422–431.CrossRefPubMed
Weinhardt LS, et al.: Effects of HIV counseling and testing on sexual risk behavior: a meta-analytic review of published research, 1985–1997. Am J Public Health 1999, 89:1397–1405.CrossRefPubMed
Sherr L, Lopman B, Kakowa M, et al.: Voluntary counselling and testing: uptake, impact on sexual behaviour, and HIV incidence in a rural Zimbabwean cohort. AIDS 2007, 21:851–860.CrossRefPubMed
Corbett EL, Makamure B, Cheung YB, et al.: HIV incidence during a cluster-randomized trial of two strategies providing voluntary counselling and testing at the workplace, Zimbabwe. AIDS 2007, 21:483–489.CrossRefPubMed
Huchko MJ, Montandon M, Nguti R, et al.: The association of HIV counseling and testing with HIV risk behaviors in a random population-based survey in Kisumu, Kenya. AIDS Behav 2009 Dec 11 (Epub ahead of print).
WHO and UNICEF: Towards universal access: Scaling up priority HIV/AIDS interventions in the health sector: Progress report 2009. Geneva, Switzerland: WHO: 2009.
Bunnell R, Ekwaru JP, Solberg P, et al.: Changes in sexual behavior and risk of HIV transmission after antiretroviral therapy and prevention interventions in rural Uganda. AIDS 2006, 20:85–92.CrossRefPubMed
Sullivan P, et al.: Is the reduction of HIV transmission risk while prescribed antiretroviral therapy (ARVT) different for men and women? Results from discordant couples in Rwanda and Zambia. In 5th IAS. Cape Town, SA; 2009.
Donnell D, Baeten JM, Kiarie J, et al.: Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet 2010, 375:2092–2098.CrossRefPubMed
Attia S, Egger M, Müller M, et al.: Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review and meta-analysis. AIDS 2009, 23:1397–1404.CrossRefPubMed
Montaner J, Wood E, Kerr T, et al.: Association of expanded HAART coverage with a decrease in new HIV diagnoses, particularly among injection drug users in British Columbia, Canada [Paper 88LB]. Presented at the 17th Conference on Retroviruses and Opportunistic Infections. San Francisco, CA; February 16–19, 2010.
Das-Douglas M, Chu, Santos GM, et al.: Decreases in community viral load are associated with a reduction in new HIV diagnoses in San Francisco [Paper #33]. Presented at the 17th Conference on Retroviruses and Opportunistic Infections. San Francisco, CA; February 16–19, 2010.
Kalichman SC, Di Berto G, Eaton L: Human immunodeficiency virus viral load in blood plasma and semen: review and implications of empirical findings. Sex Transm Dis 2008, 35:55–60.CrossRefPubMed
Amico KR, Harman JJ, Johnson BT: Efficacy of antiretroviral therapy adherence interventions: a research synthesis of trials, 1996 to 2004. J Acquir Immune Defic Syndr 2006, 41:285–297.CrossRefPubMed
Simoni JM, et al.: Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load. A meta-analytic review of randomized controlled trials. J Acquir Immune Defic Syndr 2006, 43(Suppl 1):S23–S35.PubMed
WHO: Rapid advice: antiretroviral therapy for HIV infection in adults and adolescents: Geneva, Switzerland: WHO.
Holmes KK, Levine R, Weaver M: Effectiveness of condoms in preventing sexually transmitted infections. Bull World Health Organ 2004, 82:454–461.PubMed
Johnson BT, et al.: Sexual risk reduction for persons living with HIV: research synthesis of randomized controlled trials, 1993 to 2004. J Acquir Immune Defic Syndr 2006, 41:642–650.CrossRefPubMed
Crepaz N, Lyles CM, Wolitski RJ, et al.: Do prevention interventions reduce HIV risk behaviours among people living with HIV? A meta-analytic review of controlled trials. AIDS 2006, 20:143–157.CrossRefPubMed
Horvath T, et al.: Interventions for preventing late postnatal mother-to-child transmission of HIV. Cochrane Database Syst Rev 2009, CD006734.
Des Jarlais DC, Marmor M, Paone D, et al.: HIV incidence among injecting drug users in New York City syringe-exchange programmes. Lancet 1996, 348:987–991.CrossRefPubMed
Copenhaver MM, Johnson BT, Lee IC, et al.: Behavioral HIV risk reduction among people who inject drugs: meta-analytic evidence of efficacy. J Subst Abuse Treat 2006, 31:163–171.CrossRefPubMed
Malta M, Magnanini MM, Strathdee SA, Bastos FI: Adherence to antiretroviral therapy among HIV-infected drug users: a meta-analysis. AIDS Behav 2008, 14:731–747.CrossRefPubMed
Vermund SH, et al.: Addressing research priorities for prevention of HIV infection in the United States. Clin Infect Dis 2010, 50(Suppl 3):S149–S155.CrossRefPubMed
Zachariah R, Harries AD, Philips M, et al.: Antiretroviral therapy for HIV prevention: many concerns and challenges, but are there ways forward in sub-Saharan Africa? Trans R Soc Trop Med Hyg 2010, 104:387–391.CrossRefPubMed
McCoy SI, Kangwende RA, Padian NS: Behavior change interventions to prevent HIV infection among women living in low and middle income countries: a systematic review. AIDS Behav 2010, 14:469–482.CrossRefPubMed
•• Karim QA, Karim SS, Frohlich JA, et al.: Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010 Jul 19 (Epub ahead of print). This is the first evidence that a topically applied (ART-containing) microbicide can provide protection from HIV among at-risk women: 1% tenofovir gel reduced HIV acquisition by an estimated 39% overall and by 54% in women with high gel adherence.
Mills E, Cooper C, Anema A, Guyatt G: Male circumcision for the prevention of heterosexually acquired HIV infection: a meta-analysis of randomized trials involving 11,050 men. HIV Med 2008, 9:332–335.CrossRefPubMed
Weiss HA, Hankins CA, Dickson K: Male circumcision and risk of HIV infection in women: a systematic review and meta-analysis. Lancet Infect Dis 2009, 9:669–677.CrossRefPubMed
Grosskurth H, Mosha F, Todd J, et al.: Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: randomised controlled trial. Lancet 1995, 346:530–536.CrossRefPubMed
Ozler B, et al.: Cash payments can reduce HIV/STIs in Africa—New Bank studies. News release No. 2011//027/HDN, at IAS Meeting. Vienna; July 18, 2010.
Merson M, Padian N, Coates TJ, et al.: Combination HIV prevention. Lancet 2008, 372:1805–1806.CrossRefPubMed
Buse K, Dickinson C, Sidibe M: HIV: know your epidemic, act on its politics. J R Soc Med 2008, 101:572–573.CrossRefPubMed
Grassly NC, Garnett GP, Schwartländer B, et al.: The effectiveness of HIV prevention and the epidemiological context. Bull World Health Organ 2001, 79:1121–1132.PubMed
Hughes JP, Kulich M: Cluster randomized trials for HIV prevention. Curr Opin HIV AIDS 2006, 1:471–475.CrossRefPubMed
DeGruttola V, et al.: Developing and evaluating comprehensive HIV infection control strategies: issues and challenges. Clin Infect Dis 2010, 50(Suppl 3):S102–S107.CrossRefPubMed
Anderson RM: Transmission dynamics of sexually transmitted infections. In Sexually Transmitted Diseases, edn 3. Edited by Holmes K, Sparling PF, Mardh PA, et al. New York: McGraw-Hill; 1998.
Kurth A, Spielberg F: Individual-level risk assessment for STD/HIV infection. In Sexually Transmitted Diseases, edn 4. Edited by Holmes K, Sparling PF, Stamm W, et al. New York: McGraw-Hill; 2008.