Current HIV/AIDS Reports

, Volume 8, Issue 1, pp 62–72

Combination HIV Prevention: Significance, Challenges, and Opportunities

  • Ann E. Kurth
  • Connie Celum
  • Jared M. Baeten
  • Sten H. Vermund
  • Judith N. Wasserheit
Article

DOI: 10.1007/s11904-010-0063-3

Cite this article as:
Kurth, A.E., Celum, C., Baeten, J.M. et al. Curr HIV/AIDS Rep (2011) 8: 62. doi:10.1007/s11904-010-0063-3

Abstract

No single HIV prevention strategy will be sufficient to control the HIV pandemic. However, a growing number of interventions have shown promise in partially protecting against HIV transmission and acquisition, including knowledge of HIV serostatus, behavioral risk reduction, condoms, male circumcision, needle exchange, treatment of curable sexually transmitted infections, and use of systemic and topical antiretroviral medications by both HIV-infected and uninfected persons. Designing the optimal package of interventions that matches the epidemiologic profile of a target population, delivering that package at the population level, and evaluating safety, acceptability, coverage, and effectiveness, all involve methodological challenges. Nonetheless, there is an unprecedented opportunity to develop “prevention packages” that combine various arrays of evidence-based strategies, tailored to the needs of diverse subgroups and targeted to achieve high coverage for a measurable reduction in population-level HIV transmission. HIV prevention strategies that combine partially effective interventions should be scaled up and evaluated.

Keywords

Combination HIV preventionHIV prevention methodsHIV prevention packagesAntiretroviral therapyTest and treat

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ann E. Kurth
    • 1
    • 3
  • Connie Celum
    • 2
    • 3
  • Jared M. Baeten
    • 2
    • 3
  • Sten H. Vermund
    • 4
    • 5
  • Judith N. Wasserheit
    • 2
    • 3
  1. 1.New York University College of NursingNew YorkUSA
  2. 2.Department of MedicineUniversity of WashingtonSeattleUSA
  3. 3.Department of Global HealthUniversity of WashingtonSeattleUSA
  4. 4.Vanderbilt Institute for Global HealthVanderbilt University School of MedicineNashvilleUSA
  5. 5.Department of PediatricsVanderbilt University School of MedicineNashvilleUSA