Current HIV/AIDS Reports

, Volume 7, Issue 4, pp 201-209

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Pre-exposure Prophylaxis State of the Science: Empirical Analogies for Research and Implementation

  • Sarit A. GolubAffiliated withDepartment of Psychology, Hunter College of the City University of New York, Center for HIV Educational Studies and Training Email author 
  • , Don OperarioAffiliated withProgram in Public Health, Department of Behavioral and Social Sciences, Brown University
  • , Pamina M. GorbachAffiliated withBehavioral Epidemiology Research Group, Department of Epidemiology, University of California, Los Angeles


Pre-exposure prophylaxis (PrEP) has the potential to become a powerful biomedical approach to HIV prevention; however, its success depends on behavioral and social factors that may determine its appropriate use. This article is designed to facilitate interdisciplinary empirical analogies relevant to PrEP implementation, reviewing behavioral and social science findings that may provide lessons critical to the success of PrEP as a biomedical–behavioral prevention strategy. As we prepare for the dissemination of new biomedical approaches to HIV prevention, integrating the state of the science across disciplines may result in innovative strategies for implementation that can enhance their success.


HIV Pre-exposure prophylaxis (PrEP) Adherence Risk reduction Decision-sciences Risk analysis Health communication