Current HIV/AIDS Reports

, Volume 4, Issue 1, pp 22–28

Bacterial vaginosis and host immunity

  • Elizabeth St. John
  • Debra Mares
  • Gregory T. Spear
Article

DOI: 10.1007/s11904-007-0004-y

Cite this article as:
St. John, E., Mares, D. & Spear, G.T. Curr HIV/AIDS Rep (2007) 4: 22. doi:10.1007/s11904-007-0004-y

Abstract

Bacterial vaginosis (BV) has been associated with severe medical consequences including induction of preterm birth and increasing susceptibility to infection by HIV and other genital tract pathogens. Although the mechanism by which BV induces these changes is not yet fully defined, the presence of BV is accompanied by immunologic changes in the lower genital tract environment. The most striking change is the induction of higher levels of proinflammatory cytokines, although this is not accompanied by increased levels of neutrophils. Increased cytokine levels are likely induced by bacterial products present in BV through innate immune recognition pathways such as the toll-like receptors. Recent studies show that changes in HIV susceptibility and HIV detection are associated with changes in bacterial flora. Further research is needed to identify the relative contributions of immune pathways and bacterial flora toward the pathogenic alterations that occur in BV.

Copyright information

© Current Medicine Group LLC 2007

Authors and Affiliations

  • Elizabeth St. John
  • Debra Mares
  • Gregory T. Spear
    • 1
  1. 1.Department of Immunology/MicrobiologyRush University Medical CenterChicagoUSA