Current Hepatitis Reports

, Volume 10, Issue 3, pp 186–195

Hepatitis C Virus and Innate Immunity: Taking a Fresh Look into an Old Issue


DOI: 10.1007/s11901-011-0106-2

Cite this article as:
Seetharam, A. & Crippin, J.S. Curr Hepatitis Rep (2011) 10: 186. doi:10.1007/s11901-011-0106-2


The innate immune response represents the first line of defense against hepatitis C virus (HCV) infection. The response is an early, coordinated effort orchestrated by host interferon (IFN) production, natural killer cell activation, and dendritic cell maturation, which, when effective, primes a successful adaptive immune response, leading to resolution of infection. Numerous mechanisms allow subversion of innate immunity, often establishing chronicity and resistance to conventional antiviral therapy. Recent groundbreaking studies examining viral evasion of host defenses and genetic host determinants of response to IFN have advanced our understanding of the innate immune response to HCV. This has provided the framework for individualized treatment approaches and the development of novel therapeutics aimed at restoring innate immune signaling during chronic infection. The objective of this report is to review advances in our understanding of HCV and host innate immune defenses, and to highlight their clinical translation.


Hepatitis C VirusInnate immunityInterferonNK cellDendritic cellGenome wide association studySingle nucleotide polymorphismIL-28BInterferon lambdaProtease inhibitor

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Internal Medicine/Division of GastroenterologyWashington University School of MedicineSt. LouisUSA