, Volume 6, Issue 3, pp 103-113
Date: 26 Apr 2009

Viral hepatitis in patients with HIV infection

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Coinfection with HIV and viral hepatitis substantially alters the natural course of viral hepatitis as well as its management. Therapy for infection with hepatitis B virus (HBV) in HIV-coinfected patients requires consideration of several factors, such as whether the antiviral activity of a particular agent is specific for HBV or for both viruses, the potential for drug resistance and cross-resistance, and the potential for hepatotoxicity. In most trials, response to treatment for infection with the hepatitis C virus (HCV) seems to be lower in HCV/HIV-coinfected patients than in those infected with HCV alone. Despite the current recommendations for treating hepatitis C in the setting of HIV, a large percentage of patients do not receive therapy.