, Volume 5, Issue 4, pp 133-141

Extrahepatic manifestations of HCV infection: A brief review and update

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Hepatitis C affects approximately 3% of the population worldwide and extrahepatic manifestations may occur in nearly 40% of all patients. Recent efforts have focused on incidence, prevalence, clinical significance, mechanism of disease, and the role of antiviral therapy in treatment. Cryoglobulinemia, cryoglobulinemic vasculitis, membranoproliferative glomerulonephritis, and lymphoproliferative disorders have a well-established link to hepatitis C, and many other endocrine, autoimmune, and dermatologic associations may exist. This article reviews the recent literature detailing the extrahepatic manifestations of chronic hepatitis C.