, Volume 4, Issue 4, pp 153-157

Obesity, insulin resistance, and HCV: Implications for pathogenesis

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A significant number of patients with chronic hepatitis C are overweight or obese. Insulin resistance and diabetes mellitus are also frequently encountered, and the association of hepatitis C with hepatic steatosis is well described. Both host and viral factors contribute to insulin resistance, diabetes, and hepatic steatosis. Fibrosis progression is closely linked to insulin resistance and hepatic steatosis. Obesity may contribute to hepatic fibrosis directly through induction of inflammatory pathways or indirectly via development of hepatic steatosis and insulin resistance.