, Volume 3, Issue 1, pp 30-37

Recent peginterferon and ribavirin combination trials

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Peginterferon alpha and ribavirin combination is the recommended first choice therapeutic regimen for chronic hepatitis C. Therapy duration and ribavirin dose are individualized according to the hepatitis C virus genotype. Patients with genotype 1 require 48-week courses with the usual ribavirin doses, whereas 24-week courses with lower ribavirin doses are sufficient for patients with genotype 2/3. In patients with genotype 1, the absence of an early (week 12) virologic response means no chance for sustained response and signals therapy discontinuation.