Frontline Therapy of AML: Should the Older Patient be Treated Differently?
- James M. ForanAffiliated withMayo Clinic Cancer Center, Division of Hematology & Medical Oncology, Mayo Clinic Florida Email author
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Optimal treatment of acute myeloid leukemia (AML) in older adults (age ≥60 years) remains largely undefined, in part because of the inadequate response to available therapies, the poor prognosis relative to younger adults, the heterogeneity of the population, and the difficulty in determining who is fit for intensive therapy. In contrast to younger patients, there remains uncertainty about disease biology and molecular prognostic factors in elderly AML. While almost all patients may benefit from treatment, with the exception of reduced intensity allogeneic transplantation, there is little evidence that further intensifying therapy will improve outcomes. In fact, recent studies suggest that de-intensified treatment may in fact be superior and allow access to therapy for more patients. Both the disease and the patient must be approached holistically in order to make the best frontline treatment choice together. It is critical that we support well-designed clinical trials to develop more effective frontline therapies, develop more informative biomarkers, and to better understand who is a candidate for curative treatment.
KeywordsAcute myeloid leukemia Frontline therapy Elderly patients De-intensified treatment
- Frontline Therapy of AML: Should the Older Patient be Treated Differently?
Current Hematologic Malignancy Reports
Volume 9, Issue 2 , pp 100-108
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Acute myeloid leukemia
- Frontline therapy
- Elderly patients
- De-intensified treatment
- Industry Sectors
- James M. Foran (1)
- Author Affiliations
- 1. Mayo Clinic Cancer Center, Division of Hematology & Medical Oncology, Mayo Clinic Florida, 4500 San Pablo Road, Jacksonville, FL, 32224, USA