Current Hematologic Malignancy Reports

, Volume 9, Issue 1, pp 44–49

Bruton’s Tyrosine Kinase (BTK) Inhibitors in Clinical Trials

Chronic Leukemias (S O’Brien, Section Editor)

DOI: 10.1007/s11899-013-0188-8

Cite this article as:
Burger, J.A. Curr Hematol Malig Rep (2014) 9: 44. doi:10.1007/s11899-013-0188-8

Abstract

BTK is a cytoplasmic, non-receptor tyrosine kinase that transmits signals from a variety of cell-surface molecules, including the B-cell receptor (BCR) and tissue homing receptors. Genetic BTK deletion causes B-cell immunodeficiency in humans and mice, making this kinase an attractive therapeutic target for B-cell disorders. The BTK inhibitor ibrutinib (PCI-32765, brand name: Imbruvica) demonstrated high clinical activity in B-cell malignancies, especially in patients with chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and Waldenstrom's macroglobulinemia (WM). Therefore, ibrutinib was granted a ‘breakthrough therapy’ designation for these indications and was recently approved for the treatment of relapsed MCL by the U.S. Food and Drug Administration. Other BTK inhibitors in earlier clinical development include CC-292 (AVL-292), and ONO-4059. In CLL and MCL, ibrutinib characteristically induces redistribution of malignant B cells from tissue sites into the peripheral blood, along with rapid resolution of enlarged lymph nodes and a surge in lymphocytosis. With continuous ibrutinib therapy, growth- and survival-inhibitory activities of ibrutinib result in the normalization of lymphocyte counts and remissions in a majority of patients. This review discusses the clinical advances with BTK inhibitor therapy, as well as its pathophysiological basis, and outlines perspectives for future use of BTK inhibitors.

Keywords

Chronic lymphocytic leukemiaCLLMicroenvironmentB cell receptorBCRBTKibrutinibCC-292

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of LeukemiaThe University of Texas MD Anderson Cancer CenterHoustonUSA