Chronic Leukemias (J Goldman, Section Editor)

Current Hematologic Malignancy Reports

, Volume 8, Issue 1, pp 43-51

Allogeneic Stem Cell Transplantation for Chronic Myeloid Leukemia

  • Jiří PavlůAffiliated withImperial College London at Hammersmith HospitalDepartment of Haematology, Imperial College Healthcare NHS Trust, Hammersmith Hospital Email author 
  • , Jane F. ApperleyAffiliated withImperial College London at Hammersmith HospitalCentre for Haematology, Faculty of Medicine

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Abstract

In recent years new, more potent tyrosine-kinase inhibitors have been introduced to accompany imatinib for the treatment of chronic myeloid leukemia. Most patients in chronic phase obtain an optimal response to these oral agents with minimal toxicity. Allogeneic stem cell transplantation is therefore indicated only in a minority of patients who do not achieve an adequate response to first, second or third generation agents. Patients in accelerated phase have a lower chance of achieving an optimal response on these drugs. For patients in blast phase, transplantation remains the only therapy with curative potential, although now it is increasingly used in combination with tyrosine-kinase inhibitors. In this review we address the role of allogeneic stem cell transplantation in the treatment of this disease and how patients should be transplanted.

Keywords

Chronic myeloid leukemia CML Allogeneic stem cell transplantation BMT Tyrosine-kinase inhibitor TKI Graft-versus-leukemia effect