Current Hematologic Malignancy Reports

, Volume 7, Issue 4, pp 292–299

Last Marrow Standing: Bone Marrow Transplantation for Acquired Bone Marrow Failure Conditions

Myelodysplastic Syndromes (M Sekeres, Section Editor)

DOI: 10.1007/s11899-012-0138-x

Cite this article as:
Gerds, A.T. & Scott, B.L. Curr Hematol Malig Rep (2012) 7: 292. doi:10.1007/s11899-012-0138-x

Abstract

Paroxysmal nocturnal hemoglobinuria, aplastic anemia, and myelodysplastic syndrome are a spectrum of acquired marrow failure, having a common pathologic thread of both immune dysregulation and the development of abnormal hematopoiesis. Allogeneic hematopoietic cell transplantation plays a critical role in the treatment of these disorders and, for many patients, is the only treatment modality with demonstrated curative potential. In recent years, there have been many breakthroughs in the understanding of the pathogenesis of these uncommon disorders. The subsequent advances in non-transplant therapies, along with concurrent improvement in outcomes after hematopoietic cell transplantation, necessitate continual appraisal of the indications, timing, and approaches to transplantation for acquired marrow failure syndromes. We review here contemporary and critical new findings driving current treatment decisions.

Keywords

Bone marrow transplantMyelodysplastic syndromeAplastic anemiaParoxysmal nocturnal hemoglobinuria

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  1. 1.Fred Hutchinson Cancer Research Center and the University of Washington School of MedicineSeattleUSA
  2. 2.Fred Hutchinson Cancer Research CenterSeattleUSA