Current Hematologic Malignancy Reports

, Volume 7, Issue 3, pp 208–215

Lymphomatoid Granulomatosis and Other Epstein-Barr Virus Associated Lymphoproliferative Processes

  • Kieron Dunleavy
  • Mark Roschewski
  • Wyndham H. Wilson
Lymphomas (J Armitage and P McLaughlin, Section Editors)

DOI: 10.1007/s11899-012-0132-3

Cite this article as:
Dunleavy, K., Roschewski, M. & Wilson, W.H. Curr Hematol Malig Rep (2012) 7: 208. doi:10.1007/s11899-012-0132-3

Abstract

We now recognize that the Epstein-Barr virus (EBV), which is a member of the γ- herpesvirus family, plays a pivotal role in the development of several lymphomas and lymphoproliferative disorders that include B-cell, T-cell and NK-cell processes. While over recent years, EBV associated lymphomas that arise in patients with known defects in cellular immunity are relatively well characterized, these diseases are becoming increasingly recognized in patients without overt immunodeficiency. Improved understanding of the biology of these lymphomas including elucidating the role that EBV plays in their pathogenesis has paved the way for improved therapies targeted at critical signaling pathways as well as the development of novel cellular therapies. In this review, we focus on recent progress that has been made in the biology and treatment of the rare EBV-associated disorder lymphomatoid granulomatosis (LYG) and also discuss other EBV-associated processes that occur in both immunocompetent and immunocompromised hosts.

Keywords

Lymphomatoid granulomatosisLYGEpstein-Barr virusEBVLymphomaLMP-1EBNA-1Lymphoproliferative disordersCytotoxic T-lymphocyteCellular therapyInterferon

Copyright information

© Springer Science+Business Media, LLC (outside the USA) 2012

Authors and Affiliations

  • Kieron Dunleavy
    • 1
    • 2
  • Mark Roschewski
    • 1
  • Wyndham H. Wilson
    • 1
  1. 1.Metabolism Branch, Center for Cancer Research, National Cancer InstituteBethesdaUSA
  2. 2.Metabolism Branch, National Cancer InstituteBethesdaUSA