Current Hematologic Malignancy Reports

, Volume 7, Issue 1, pp 3–12

Can Prognostic Factors Be Used to Direct Therapy in Chronic Lymphocytic Leukemia?

  • Leopold Sellner
  • Sascha Dietrich
  • Peter Dreger
  • Hanno Glimm
  • Thorsten Zenz
Chronic Lymphocytic Leukemia (S O'Brien, Section Editor)

DOI: 10.1007/s11899-011-0110-1

Cite this article as:
Sellner, L., Dietrich, S., Dreger, P. et al. Curr Hematol Malig Rep (2012) 7: 3. doi:10.1007/s11899-011-0110-1

Abstract

Chronic lymphocytic leukemia (CLL) shows a heterogeneous clinical course, which can be explained in part by prognostic factors. Most patients do not need treatment at the time of first diagnosis. The identification of prognostic factors is of major interest if strategies can be devised to treat patients according to their individual risk profile or biological subgroup. Currently, in spite of a wealth of prognostic factors, individualized treatment approaches in different genetic or risk groups are the exemption in CLL. This review summarizes the most important prognostic and predictive factors in CLL, with particular emphasis on factors affecting treatment decisions in clinical trials and routine practice.

Keywords

Chronic lymphocytic leukemia CLL Predictive factors Allogeneic Early treatment Maintenance Consolidation 17p deletion 11q deletion TP53 IGHV MRD 

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Leopold Sellner
    • 1
  • Sascha Dietrich
    • 1
  • Peter Dreger
    • 1
  • Hanno Glimm
    • 2
  • Thorsten Zenz
    • 1
    • 2
  1. 1.Department of Medicine VUniversity Hospital HeidelbergHeidelbergGermany
  2. 2.Department of Translational OncologyNational Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)HeidelbergGermany