Current Hematologic Malignancy Reports

, Volume 1, Issue 1, pp 16–19

Lenalidomide (Revlimid, CC-5013) in myelodysplastic syndromes: Is it any good?

Article

DOI: 10.1007/s11899-006-0012-9

Cite this article as:
Sekeres, M.A. & List, A. Curr Hematol Malig Rep (2006) 1: 16. doi:10.1007/s11899-006-0012-9

Abstract

The myelodysplastic syndromes (MDS) can be divided into "early" and "advanced" disease by evaluation of prognostic variables such as the number of cytopenias, karyotype, and percentage of myeloblasts. Patients with an isolated interstitial deletion of chromosome 5q31 represent a distinct subset who may derive particular benefit from immunomodulatory drugs. Goals of therapy for early MDS focus on hematologic improvement and maximizing quality of life. Thalidomide, the prototype of the immunomodulatory drugs, yields major erythroid responses in some patients with early MDS, but doselimiting neurologic toxicities limit its potential clinical benefit. Lenalidomide, a more potent and non-neurotoxic derivative, has shown promising results in early MDS, yielding hematologic improvement in almost half of patients and transfusion independence with cytogenetic remissions in approximately two thirds of patients harboring the chromosome 5q31 deletion.

Copyright information

© Current Science Inc 2006

Authors and Affiliations

  1. 1.H. Lee Moffitt Cancer Center & Research InstituteUniversity of South FloridaTampaUSA

Personalised recommendations