Current Heart Failure Reports

, Volume 11, Issue 2, pp 156–165

Heart Failure and Obesity in Adults: Pathophysiology, Clinical Manifestations and Management

Authors

    • University-Columbia Division of Cardiovascular MedicineUniversity of Missouri Health Sciences Center
  • Harsh Agrawal
    • University-Columbia Division of Cardiovascular MedicineUniversity of Missouri Health Sciences Center
  • Kul Aggarwal
    • University-Columbia Division of Cardiovascular MedicineUniversity of Missouri Health Sciences Center
  • Senthil A. Kumar
    • University-Columbia Division of Cardiovascular MedicineUniversity of Missouri Health Sciences Center
  • Arun Kumar
    • University-Columbia Division of Cardiovascular MedicineUniversity of Missouri Health Sciences Center
Pathophysiology: Neuroendocrine, Vascular, and Metabolic Factors (SD Katz, Section Editor)

DOI: 10.1007/s11897-014-0197-5

Cite this article as:
Alpert, M.A., Agrawal, H., Aggarwal, K. et al. Curr Heart Fail Rep (2014) 11: 156. doi:10.1007/s11897-014-0197-5

Abstract

Obesity is both a risk factor and a direct cause of heart failure (HF) in adults. Severe obesity produces hemodynamic alterations that predispose to changes in left ventricular morphology and function, which, over time, may lend to the development of HF (obesity cardiomyopathy). Certain neurohormonal and metabolic abnormalities as well as cardiovascular co-morbidities may facilitate this process. Substantial purposeful weight loss is capable of reversing most of the alterations in cardiac performance and morphology and may improve functional capacity and quality of life in patents with obesity cardiomyopathy.

Keywords

ObesitySevere obesityObesity cardiomyopathyHeart failureEpidemiologyPathophysiologyRisk factorObesity paradoxCentral hemodynamicsLeft ventricular massLeft ventricular hypertrophyLeft ventricular diastolic chamber sizeLeft ventricular geometryConcentric and eccentric hypertrophyLeft ventricular diastolic dysfunctionLeft ventricular systolic dysfunctionTissue Doppler imagingNeurohormonal and metabolic alterationsSystemic hypertensionClinical manifestationsMedical therapyWeight loss

Copyright information

© Springer Science+Business Media New York 2014