Current Heart Failure Reports

, Volume 10, Issue 4, pp 350–358

Circulating Biomarkers in Patients with Heart Failure and Preserved Ejection Fraction

  • Eileen O’Meara
  • Simon de Denus
  • Jean-Lucien Rouleau
  • Akshay Desai
Pathophysiology of Myocardial Failure (IS Anand and M Sarraf, Section Editors)

DOI: 10.1007/s11897-013-0160-x

Cite this article as:
O’Meara, E., de Denus, S., Rouleau, JL. et al. Curr Heart Fail Rep (2013) 10: 350. doi:10.1007/s11897-013-0160-x

Abstract

Patients with heart failure with preserved ejection fraction (HF-PEF) comprise a growing proportion of the overall HF burden. The pathophysiology of HF-PEF is complex, and relates to the interplay between cardiac risk factors (notably diabetes/insulin resistance, hypertension), systemic inflammation, and comorbid medical illness (e.g. chronic kidney disease) that conspire to promote endothelial dysfunction, ventricular-vascular stiffening, and diastolic dysfunction. Efficient diagnosis and optimal therapy remain challenging in this population. Imaging, electrocardiographic, and circulating biomarkers, as well as pharmacogenetics, may help to facilitate HF diagnosis, stratify risk, and individualize therapy. In this review, we focus on established and emerging circulating biomarkers in HF-PE, including circulating biomarkers of myocyte stress, myocyte injury, renal function, systemic inflammation, and fibrosis. Such markers have contributed to better understanding of the pathophysiologic mechanisms relevant to HF-PEF, and may eventually help to facilitate more effective and personalized management of this syndrome.

Keywords

Heart failure Biomarkers Natriuretic peptides Collagen Renal function 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Eileen O’Meara
    • 1
    • 2
  • Simon de Denus
    • 1
    • 2
  • Jean-Lucien Rouleau
    • 1
    • 2
  • Akshay Desai
    • 3
    • 4
  1. 1.Montreal Heart InstituteMontrealCanada
  2. 2.Université de MontréalMontrealCanada
  3. 3.Brigham and Women’s HospitalBostonUSA
  4. 4.Harvard Medical SchoolBostonUSA

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