Current Heart Failure Reports

, Volume 10, Issue 1, pp 73–80

Stem Cell Therapy: Promising Treatment in Heart Failure?

  • John H. Loughran
  • Atul R. Chugh
  • Imtiaz Ismail
  • Roberto Bolli
Nonpharmacologic Therapy: Surgery, Ventricular Assist Devices, Biventricular Pacing, and Exercise (AK Hasan, Section Editor)

DOI: 10.1007/s11897-012-0128-2

Cite this article as:
Loughran, J.H., Chugh, A.R., Ismail, I. et al. Curr Heart Fail Rep (2013) 10: 73. doi:10.1007/s11897-012-0128-2

Abstract

Cardiac repair through the use of regenerative medicine has been a considerable research focus over the last decade. Several stem cell types have been investigated over this timeframe as potential candidates to target post-infarction heart failure. The progression of investigation through the rigors of clinical trial design has provided some answers as to the potential clinical utility of this therapy; although there are many questions that remain. This review will concentrate on the clinical trial results of stem cell therapy for cardiac repair since the turn of the century and discuss some of the points that need clarification before this form of therapy can be considered for widespread applicability.

Keywords

Stem cell therapyBone-marrow mononuclear stem cellsCADChronic ischemic heart diseaseMyogenesis

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • John H. Loughran
    • 1
  • Atul R. Chugh
    • 1
  • Imtiaz Ismail
    • 2
  • Roberto Bolli
    • 1
  1. 1.Division of Cardiovascular MedicineUniversity of LouisvilleLouisvilleUSA
  2. 2.The School of MedicineUniversity of LouisvilleLouisvilleUSA