Current Heart Failure Reports

, Volume 8, Issue 2, pp 99–105

Renal Biomarkers of Kidney Injury in Cardiorenal Syndrome


DOI: 10.1007/s11897-011-0052-x

Cite this article as:
Comnick, M. & Ishani, A. Curr Heart Fail Rep (2011) 8: 99. doi:10.1007/s11897-011-0052-x


The cardiorenal syndromes comprise a group of disorders in which impairment of either the heart or the kidney results in injury to the other. Although the pathophysiology is not yet well understood, the clinical consequences are increasingly recognized. In congestive heart failure, the development of worsening renal function is associated with increased hospitalizations and death. Urinary biomarkers offer a rapid and noninvasive method for detecting kidney injury. The role of urinary biomarkers such as neutrophil gelatinase-associated lipocalin, kidney injury molecule 1, N-acetyl-β-D-glucosaminidase, interleukin-18, and cystatin C are being investigated to provide diagnostic, prognostic, and, eventually, therapeutic information. This article reviews the utility of urinary biomarkers in congestive heart failure and explores directions for future research.


Cardiorenal syndromeHeart failureAcute kidney injuryEpidemiologyNGALCystatin CAlbuminuriaN-Acetyl-β-D-GlucosaminidaseKidney injury molecule-1Neutrophil gelatinase-associated lipocalin

Copyright information

© Springer Science+Business Media, LLC (outside the USA)  2011

Authors and Affiliations

  1. 1.Division of Renal Diseases and HypertensionUniversity of MinnesotaMinneapolisUSA
  2. 2.Minneapolis VA Health Care SystemMinneapolisUSA