Current Heart Failure Reports

, Volume 6, Issue 1, pp 57–64

Heart failure with normal ejection fraction: Consideration of mechanisms other than diastolic dysfunction

  • Travis Bench
  • Daniel Burkhoff
  • John B. O’Connell
  • Maria Rosa Costanzo
  • William T. Abraham
  • Martin St. John Sutton
  • Mathew S. Maurer
Article

DOI: 10.1007/s11897-009-0010-z

Cite this article as:
Bench, T., Burkhoff, D., O’Connell, J.B. et al. Curr Heart Fail Rep (2009) 6: 57. doi:10.1007/s11897-009-0010-z

Abstract

More than half of patients with heart failure (HF) have a normal ejection fraction (EF). These patients are typically elderly, are predominantly female, and have a high incidence of multiple comorbid conditions associated with development of ventricular hypertrophy and/or interstitial fibrosis. Thus, the cause of HF has been attributed to diastolic dysfunction. However, the same comorbidities may also impact myocardial systolic, ventricular, vascular, renal, and extracardiovascular properties in ways that can also contribute to symptoms of HF by way of mechanisms not related to diastolic dysfunction. Accordingly, the descriptive term HF with normal EF has been suggested as an alternative to the mechanistic term diastolic HF. In this article, we review the current understanding of nondiastolic mechanisms that may contribute to the HF with normal EF syndrome to highlight potential pathways for research that may lead to new targets for therapy.

Copyright information

© Current Medicine Group, LLC 2009

Authors and Affiliations

  • Travis Bench
  • Daniel Burkhoff
    • 1
  • John B. O’Connell
  • Maria Rosa Costanzo
  • William T. Abraham
  • Martin St. John Sutton
  • Mathew S. Maurer
  1. 1.Division of CardiologyColumbia UniversityNew YorkUSA

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