Current Gastroenterology Reports

, Volume 14, Issue 4, pp 306–312

Recent Advances in the Management of Difficult Constipation

Neuromuscular Disorders of the Gastrointestinal Tract (A Foxx-Orenstein, Section Editor)

DOI: 10.1007/s11894-012-0269-1

Cite this article as:
Lacy, B.E., Levenick, J. & Crowell, M. Curr Gastroenterol Rep (2012) 14: 306. doi:10.1007/s11894-012-0269-1


Constipation is a highly prevalent disorder. Some patients suffer from acute, intermittent episodes of constipation. Others, however, suffer from chronic constipation, a term that refers to those patients with symptoms of constipation for more than 6 months. In clinical practice, chronic constipation is often used interchangeably with the term functional constipation, which is currently defined using the Rome III criteria. Symptoms can be burdensome, leading to a reduction in patients’ quality of life. In addition, chronic constipation is important because it imposes a significant economic impact to the health care system. Some patients with chronic constipation have persistent symptoms despite implementing lifestyle changes and using either over-the-counter agents or prescription medications. These patients may be categorized as having difficult constipation. This report will focus on recent advances in the management of difficult constipation, and include a discussion of new and upcoming medications as well as new diagnostic tests and procedures.


Anorectal manometry Constipation Defecography Guanylate cyclase Linaclotide Prucalopride Rome criteria Sacral nerve stimulation Wireless motility capsule 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Brian E. Lacy
    • 1
  • John Levenick
    • 1
  • Michael Crowell
    • 2
  1. 1.Division of Gastroenterology & HepatologyDartmouth-Hitchcock Medical CenterLebanonUSA
  2. 2.Division of GastroenterologyMayo Clinic ScottsdaleScottsdaleUSA

Personalised recommendations