Current Gastroenterology Reports

, Volume 14, Issue 3, pp 275–281

How Does Knowledge from Translational Research Impact Our Clinical Care of Pediatric Inflammatory Bowel Disease Patients?

Pediatric Gastroenterology (SR Orenstein, Section Editor)

DOI: 10.1007/s11894-012-0258-4

Cite this article as:
Denson, L.A. Curr Gastroenterol Rep (2012) 14: 275. doi:10.1007/s11894-012-0258-4


Recent translational studies have provided new insights into pathogenesis, disease behavior, and treatment responses in pediatric Inflammatory Bowel Disease (IBD). Registry studies have identified distinct clinical phenotypes with increasing age of onset; this has led to a revision of the clinical phenotyping system, now termed the Paris classification system. It is recognized that there are infantile (age <2 years), very early onset (VEO, age 2–10), and early onset (EO, age 10–17) forms of disease. Rare genetic mutations affecting anti-microbial and anti-inflammatory pathways have been discovered in infantile and VEO forms, while genetic pathways identified in EO disease have been similar to adult-onset IBD. Genetic and serologic patterns measured soon after diagnosis have been shown to be associated with more aggressive stricturing behavior; these patterns may now be used clinically to help predict disease course. More recently, clinical and genetic models have been developed that, if validated, could be used to predict treatment responses.


ASCAANCAOmpCI2CBir1NOD2InfantileVery early onsetEarly onsetCrohn diseaseUlcerative colitisMicrobiomeDysbiosisSerologyDiagnosisPrognosisStrictureParis

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Pediatric Gastroenterology, Department of PediatricsCincinnati Children’s Hospital Medical Center and the University of Cincinnati College of MedicineCincinnatiUSA