Current Gastroenterology Reports

, Volume 10, Issue 2, pp 122–127

Genetics of pancreatitis: A guide for clinicians

  • Matthias Treiber
  • Christoph Schlag
  • Roland M. Schmid

DOI: 10.1007/s11894-008-0032-9

Cite this article as:
Treiber, M., Schlag, C. & Schmid, R.M. Curr Gastroenterol Rep (2008) 10: 122. doi:10.1007/s11894-008-0032-9


Chronic pancreatitis is an inflammatory disease of the pancreas leading to progressive fibrosis that presents with severe abdominal pain and may result in exocrine and/or endocrine insufficiency at later stages. Although alcohol is the strongest contributing factor for disease development, some patients feature none of the known classical risk factors and were consequently classified as having idiopathic or, in the presence of a positive family history, hereditary disease. Today, several mutations have been identified that predispose carriers to development of chronic pancreatitis. The genetic studies of the past decade have clearly contributed to a better understanding of the disease’s pathogenesis. Currently known mutations associated with chronic pancreatitis and the implications for clinicians are discussed in this review.

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Matthias Treiber
  • Christoph Schlag
  • Roland M. Schmid
    • 1
  1. 1.Second Medical DepartmentTechnical University of MunichMünchenGermany