Evidence-based approach to idiopathic pancreatitis
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
The causes of recurrent acute pancreatitis, including the newly recognized genetic causes, are reviewed. The pitfalls of overcalling the diagnosis of pancreatitis in patients with abdominal pain or other symptoms and the role of a careful history are emphasized. The presence of undetectable microlithiasis in patients with unexplained pancreatitis is discussed. The popular notion of pancreas divisum and sphincter of Oddi dysfunction as causes of pancreatitis is challenged, as is the role of endotherapy in these conditions.
- Levy MJ, Geenen JE: Idiopathic acute recurrent pancreatitis. Am J Gastroenterol 2001, 96:2540–2555. CrossRef
- Tarnasky PR, Hawes RH: Endoscopic diagnosis and therapy of unexplained (idiopathic) acute pancreatitis. Gastrointest Endosc 1998, 8:13–37.
- Layer P, Yamamoto H, Kalthoff L, et al.: The different courses of early-and late-onset idiopathic and alcoholic chronic pancreatitis. Gastroenterology 1994, 107:1481–1487.
- McMahon MJ, Pickford IR: Biochemical prediction of gallstones early in an attack of acute pancreatitis. Lancet 1979, 2:541–543. CrossRef
- Tenner S, Dubner H, Steinberg W: Predicting gallstone pancreatitis with laboratory parameters: a meta-analysis. Am J Gastroenterol 1994, 89:1863–1866.
- Ros E, Navarro S, Bru C, et al.: Occult microlithiasis in ‘idiopathic’ acute pancreatitis: prevention of relapses by cholecystectomy or ursodeoxycholic acid therapy. Gastroenterology 1991, 101:1701–1709.
- Lee SP, Nicholls JF, Park HZ: Biliary sludge as a cause of acute pancreatitis. N Engl J Med 1992, 326:589–593. CrossRef
- Neoptolemos JP, Hall AW, Finlay DF, et al.: The urgent diagnosis of gallstones in acute pancreatitis: a prospective study of three methods. Br J Surg 1984, 71:230–233. CrossRef
- Wang SS, Lin XZ, Tsai YT, et al.: Clinical significance of ultrasonography, computed tomography, and biochemical tests in the rapid diagnosis of gallstone-related pancreatitis: a prospective study. Pancreas 1988, 3:153–158. CrossRef
- Whitcomb DC, Gorry MC, Preston RA, et al.: Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 1996, 14:141–145. CrossRef
- Gorry MC, Gabbaizedeh D, Furey W, et al.: Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis. Gastroenterology 1997, 113:1063–1068. CrossRef
- Witt H, Luck W, Becker M: A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis. Gastroenterology 1999, 117:7–10. CrossRef
- Creighton J, Lyall R, Wilson DI, et al.: Mutations of the cationic trypsinogen gene in patients with chronic pancreatitis. Lancet 1999, 354:42–43. CrossRef
- Choo-Kang LR, Zeitlin PL: Type I, II, III, IV and V cystic fibrosis transmembrane conductance regulator defects and opportunities for therapy. Curr Opin Pulm Med 2000, 6:521–529. CrossRef
- Sharer N, Schwarz M, Malone G, et al.: Mutations of the cystic fibrosis gene in patients with chronic pancreatitis. N Engl J Med 1998, 339:645–652. See annotation for  below. CrossRef
- Cohn JA, Friedman KJ, Noone PG, et al.: Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis. N Engl J Med 1998, 339:653–658. These are the first published reports linking mutations of the cystic fibrosis gene to patients with acute and chronic pancreatitis. In these initial studies, it was not clear whether this risk was associated with having one or two CFTR mutations or concomitant mutations of other genes. CrossRef
- Noone PG, Zhou Z, Silverman LM, et al.: Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations. Gastroenterology 2001, 121:1310–1319. An updated and extended study based on Cohn et al. . These authors have examined 20 subjects for rare CFTR mutations by DNA sequencing, and 11 of these were tested for PSTI mutation. They concluded that CFTR-related pancreatitis risk was correlated with having two CFTR mutations and reduced extrapancreatic CFTR function, and that there was additional risk of simultaneous PSTI mutation. CrossRef
- Witt H, Luck W, Hennies HC, et al.: Mutations in the gene encoding the serine protease inhibitor, Kazal type 1, are associated with chronic pancreatitis. Nat Genet 2000, 25:213–216. CrossRef
- Ellis I, Lerch MM, Whitcomb DC: Genetic testing for hereditary pancreatitis: guidelines for indications, counselling, consent and privacy issues. Pancreatology 2001, 1:405–415. This report represents the consensus reached by a group of international experts on the pancreas. It provides useful information with regard to the practical issues that confront clinicians in deciding when to test patients and particularly their family members for the hereditary pancreatitis gene. CrossRef
- Delhaye M, Engelholm L, Cremer M: Pancreas divisum: congenital anatomic variant or anomaly? Contribution of endoscopic retrograde dorsal pancreatography. Gastroenterology 1985, 89:951–958.
- Lans JI, Geenen JE, Johanson JF, et al.: Endoscopic therapy in patients with pancreas divisum and acute pancreatitis: a prospective, randomized, controlled clinical trial. Gastrointest Endosc 1992, 38:430–434. CrossRef
- Choudari CP, Fogel EL, Sherman S, et al.: Pancreas divisum, pancreatitis and CFTR mutation [abstract]. Gastrointest Endosc 1999, 49:AB187.
- Quest L, Lombard M: Pancreas divisum: opinio divisa. Gut 2000, 47:317–319. CrossRef
- American Society for Gastrointestinal Endoscopy: Endoscopic pancreatic therapy: update (April 1998). Accessible online at http://www.asge.org/gui/clinical_info/new_tech/ nt_pancreatic.asp
- Ohhashi K, Murakimi Y, Maruyama M, et al.: Four cases of mucus secreting pancreatic cancer [in Japanese]. Prog Dig Endosc 1982, 20:348–351.
- Loftus EV, Olivares-Pakzad BA, Bates KP, et al.: Intraductal mucinous tumors of the pancreas: clinicopathologic features, outcome and nomenclature. Members of the Pancreas Clinic and Pancreatic Surgeons of Mayo Clinic. Gastroenterology 1996, 110:1909–1918. CrossRef
- Madura JA, Wiebke EA, Howard TJ, et al.: Mucin-hypersecreting intraductal neoplasm of the pancreas: a precursor to cystic pancreatic malignancies. Surgery 1997, 122:786–793. CrossRef
- Ballinger AB, Barnes E, Alstead EM, et al.: Is intervention necessary after a first episode of acute idiopathic pancreatitis? Gut 1996, 3:293–295.
- Dahan P, Andant C, Levy P, et al.: Prospective evaluation of endoscopic ultrasonography and microscopic examination of duodenal bile in the diagnosis of cholecystolithiasis in 45 patients with normal conventional ultrasonography. Gut 1996, 38:277–281.
- Liu C, Lo C, Chan JKF, et al.: EUS for detection of occult cholelithiasis in patients with idiopathic pancreatitis. Gastrointest Endosc 2000, 51:28–32. CrossRef
- Di Francesco V, Rigo L, Brunori MP, et al.: Comparison of ultrasound-secretin test and sphincter of Oddi manometry in patients with acute recurrent pancreatitis [abstract]. Paper presented at Digestive Disease Week. May 13–19, 1995. San Diego, CA.
- Catalano MF, Geenen JE, Schmalz MJ, et al.: Sphincter of Oddi dysfunction and papillary stenosis: diagnosis by secretin-stimulated endoscopic ultrasound (SSEUS) [abstract]. Paper presented at Digestive Disease Week. May 18–23, 1996. San Francisco, CA.
- Evidence-based approach to idiopathic pancreatitis
Current Gastroenterology Reports
Volume 4, Issue 2 , pp 128-134
- Cover Date
- Print ISSN
- Online ISSN
- Current Medicine Group
- Additional Links