Current Diabetes Reports

, 14:500

Look Inside Look AHEAD: Why the Glass Is More than Half-Full

  • Helmut Steinberg
  • Crystal Jacovino
  • Abbas E. Kitabchi
Macrovascular Complications in Diabetes (L Perreault, Section Editor)

DOI: 10.1007/s11892-014-0500-6

Cite this article as:
Steinberg, H., Jacovino, C. & Kitabchi, A.E. Curr Diab Rep (2014) 14: 500. doi:10.1007/s11892-014-0500-6
Part of the following topical collections:
  1. Topical Collection on Macrovascular Complications in Diabetes

Abstract

Look AHEAD is the only long-term study in a large cohort of subjects with type 2 diabetes that assessed the effect of intensive lifestyle, predominantly diet and exercise, on a number of outcomes. While Look AHEAD was not able to detect a significant effect of intensive lifestyle modification on cardiovascular outcomes, it clearly demonstrated numerous beneficial and sustained effects on health outcomes that are relevant to this population. Without the exceptional retention of study participants, it would have been difficult to detect these benefits. Our review provides a perspective on aspects related to exercise, diet, and weight loss in relation to cardiovascular outcomes and potential future research.

Keywords

Intensive lifestyle modificationDietWeight lossExerciseFitnessBenefitsLook AHEAD

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Helmut Steinberg
    • 1
  • Crystal Jacovino
    • 1
  • Abbas E. Kitabchi
    • 1
  1. 1.Division of Endocrinology, Diabetes, and MetabolismUniversity of Tennessee Health Science CenterMemphisUSA