Pharmacologic Treatment of Type 2 Diabetes (A Vella, Section Editor)

Current Diabetes Reports

, 14:478

First online:

Systematic Reviews to Ascertain the Safety of Diabetes Medications

  • Michael R. GionfriddoAffiliated withKnowledge and Evaluation Research Unit, Mayo ClinicMayo Graduate School, Mayo Clinic
  • , Oscar L. Morey-VargasAffiliated withKnowledge and Evaluation Research Unit, Mayo ClinicDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic
  • , Juan P. BritoAffiliated withKnowledge and Evaluation Research Unit, Mayo ClinicDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic
  • , Aaron L. LeppinAffiliated withKnowledge and Evaluation Research Unit, Mayo Clinic
  • , M. Hassan MuradAffiliated withKnowledge and Evaluation Research Unit, Mayo ClinicDivision of Preventive, Occupational and Aerospace Medicine, Division of Health Care Policy and Research, Mayo Clinic
  • , Victor M. MontoriAffiliated withKnowledge and Evaluation Research Unit, Mayo ClinicDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic Email author 

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Abstract

Clinicians and patients with type 2 diabetes enjoy an expanding list of medications to improve glycemic control. With this expansion has come a flurry of concerns about the safety of these antihyperglycemic agents, concerns that affect judgments about the risk/benefit balance of therapy. Some of these safety signals have been identified through the synthesis of existing research evidence. Thus, it has become important for clinicians and clinical policymakers to understand the strengths and limitations of systematic reviews and meta-analyses in determining the safety of diabetes medications. In this paper, we highlight key safety concerns with diabetes medications and discuss the role evidence synthesis plays in each, with special attention to its strengths and limitations.

Keywords

Systematic review Meta-analysis Diabetes Safety Diabetes medications