Current Diabetes Reports

, 14:478

Systematic Reviews to Ascertain the Safety of Diabetes Medications

  • Michael R. Gionfriddo
  • Oscar L. Morey-Vargas
  • Juan P. Brito
  • Aaron L. Leppin
  • M. Hassan Murad
  • Victor M. Montori
Pharmacologic Treatment of Type 2 Diabetes (A Vella, Section Editor)

DOI: 10.1007/s11892-014-0478-0

Cite this article as:
Gionfriddo, M.R., Morey-Vargas, O.L., Brito, J.P. et al. Curr Diab Rep (2014) 14: 478. doi:10.1007/s11892-014-0478-0
Part of the following topical collections:
  1. Topical Collection on Pharmacologic Treatment of Type 2 Diabetes

Abstract

Clinicians and patients with type 2 diabetes enjoy an expanding list of medications to improve glycemic control. With this expansion has come a flurry of concerns about the safety of these antihyperglycemic agents, concerns that affect judgments about the risk/benefit balance of therapy. Some of these safety signals have been identified through the synthesis of existing research evidence. Thus, it has become important for clinicians and clinical policymakers to understand the strengths and limitations of systematic reviews and meta-analyses in determining the safety of diabetes medications. In this paper, we highlight key safety concerns with diabetes medications and discuss the role evidence synthesis plays in each, with special attention to its strengths and limitations.

Keywords

Systematic reviewMeta-analysisDiabetesSafetyDiabetes medications

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Michael R. Gionfriddo
    • 1
    • 2
  • Oscar L. Morey-Vargas
    • 1
    • 3
  • Juan P. Brito
    • 1
    • 3
  • Aaron L. Leppin
    • 1
  • M. Hassan Murad
    • 1
    • 4
  • Victor M. Montori
    • 1
    • 3
  1. 1.Knowledge and Evaluation Research UnitMayo ClinicRochesterUSA
  2. 2.Mayo Graduate SchoolMayo ClinicRochesterUSA
  3. 3.Division of Endocrinology, Diabetes, Metabolism, and NutritionMayo ClinicRochesterUSA
  4. 4.Division of Preventive, Occupational and Aerospace Medicine, Division of Health Care Policy and ResearchMayo ClinicRochesterUSA