Current Diabetes Reports

, Volume 13, Issue 3, pp 435–444

Diabetes Mellitus and Inflammation

Authors

  • Eric Lontchi-Yimagou
    • Laboratory for Molecular and Metabolic Diseases, Biotechnology CenterUniversity of Yaoundé 1
  • Eugene Sobngwi
    • National Obesity CenterYaounde Central Hospital and Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1
    • Institute of Health and SocietyNewcastle University
  • Tandi E. Matsha
    • Department of Biomedical Sciences, Faculty of Health and Wellness ScienceCape Peninsula University of Technology
    • South African Medical Research Council & University of Cape Town
    • The George Institute for Global Health
    • Julius Center for Health Sciences and Primary CareUniversity Medical Center Utrecht
Diabetes and Other Diseases—Emerging Associations (D Aron, Section Editor)

DOI: 10.1007/s11892-013-0375-y

Cite this article as:
Lontchi-Yimagou, E., Sobngwi, E., Matsha, T.E. et al. Curr Diab Rep (2013) 13: 435. doi:10.1007/s11892-013-0375-y

Abstract

Type 2 diabetes mellitus (T2DM) is increasingly common worldwide. Related complications account for increased morbidity and mortality, and enormous healthcare spending. Knowledge of the pathophysiological derangements involved in the occurrence of diabetes and related complications is critical for successful prevention and control solutions. Epidemiologic studies have established an association between inflammatory biomarkers and the occurrence of T2DM and complications. Adipose tissue appears to be a major site of production of those inflammatory biomarkers, as a result of the cross-talk between adipose cells, macrophages, and other immune cells that infiltrate the expanding adipose tissue. The triggering mechanisms of the inflammation in T2DM are still ill-understood. Inflammatory response likely contributes to T2DM occurrence by causing insulin resistance, and is in turn intensified in the presence of hyperglycemia to promote long-term complications of diabetes. Targeting inflammatory pathways could possibly be a component of the strategies to prevent and control diabetes and related complications.

Keywords

Diabetes mellitusInflammationBiomarkersAdipocytesCytokinesAdipokinesInterleukin

Copyright information

© Springer Science+Business Media New York 2013