Current Diabetes Reports

, Volume 12, Issue 5, pp 551–559

Metabolic Memory and Chronic Diabetes Complications: Potential Role for Epigenetic Mechanisms

Treatment of Type 1 Diabetes (D Dabelea, Section Editor)

DOI: 10.1007/s11892-012-0302-7

Cite this article as:
Intine, R.V. & Sarras, M.P. Curr Diab Rep (2012) 12: 551. doi:10.1007/s11892-012-0302-7


Recent estimates indicate that diabetes mellitus currently affects more than 10 % of the world’s population. Evidence from both the laboratory and large scale clinical trials has revealed that prolonged hyperglycemia induces chronic complications which persist and progress unimpeded even when glycemic control is pharmaceutically achieved via the phenomenon of metabolic memory. The epigenome is comprised of all chromatin modifications including post translational histone modification, expression control via miRNAs and the methylation of cytosine within DNA. Modifications of these epigenetic marks not only allow cells and organisms to quickly respond to changing environmental stimuli but also confer the ability of the cell to “memorize” these encounters. As such, these processes have gained much attention as potential molecular mechanisms underlying metabolic memory and chronic diabetic complications. Here we present a review of the very recent literature published pertaining to this subject.


Chronic diabetic complications Epigenetics Metabolic memory 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Dr. William M. Scholl College of Podiatric MedicineRosalind Franklin University of Medicine and ScienceNorth ChicagoUSA
  2. 2.Department of Cell, Biology, and Anatomy, Chicago Medical SchoolRosalind Franklin University of Medicine and ScienceNorth ChicagoUSA