, Volume 11, Issue 6, pp 467-469
Date: 16 Aug 2011

Does Metformin Work for Everyone? A Genome-wide Association Study for Metformin Response

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Trial:

Zhou K, Bellenguez C, Spencer CC, et al.: Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet 2011, 43:117–120.

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Of importance

Introduction:

Metformin is the first-line agent universally recommended by expert consensus panels, such as those convened by the American Diabetes Association, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists/American College of Endocrinology [13]. Thus, absent contraindications such as liver or kidney failure, every patient with type 2 diabetes is prescribed metformin upfront. When glycemic treatment targets are not met, typical algorithms and current clinical practice recommend the addition of a second medication. Anecdotal clinical experience and evidence gathered from both observational studies and clinical trials [4] suggest that a substantial proportion of patients will eventually fail metformin monotherapy, and that a nontrivial s ...