The Past, Present, and Future of Genetic Associations in Type 1 Diabetes Authors
First Online: 27 July 2011 DOI:
Cite this article as: Baker, P.R. & Steck, A.K. Curr Diab Rep (2011) 11: 445. doi:10.1007/s11892-011-0212-0
Type 1 diabetes mellitus (T1DM) is an autoimmune disease affecting approximately one in 300 individuals in the United States. The majority of genetic research to date has focused on the heritability that predisposes to islet autoimmunity and T1DM. The evidence so far points to T1DM being a polygenic, common, complex disease with major susceptibility lying in the major histocompatibility complex (MHC) on chromosome 6 with other smaller effects seen in loci outside of the MHC. With recent advances in technology, novel means of exploring the human genome have given way to new information in the development of T1DM. The newest technologies, namely high-throughput polymorphism typing and sequencing, have led to a paradigm shift in studying common diseases such as T1DM. In this review we highlight the advances in genetic associations in T1DM in the last several decades and how they have led to a better understanding of T1DM pathogenesis.
Type 1 diabetes
Major histocompatibility complex
Human leukocyte antigen
Genetic association study
Single nucleotide polymorphism
Genome-wide association study
Whole exome sequencing
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