Current Diabetes Reports

, Volume 11, Issue 4, pp 275–284

Painful Diabetic Neuropathy is More than Pain Alone: Examining the Role of Anxiety and Depression as Mediators and Complicators

  • Rakesh Jain
  • Shailesh Jain
  • Charles L. Raison
  • Vladimir Maletic

DOI: 10.1007/s11892-011-0202-2

Cite this article as:
Jain, R., Jain, S., Raison, C.L. et al. Curr Diab Rep (2011) 11: 275. doi:10.1007/s11892-011-0202-2


A wealth of information exists regarding the plight of patients suffering with diabetic peripheral neuropathic pain (DPNP). Although physical pain is certainly a primary challenge in the management of this condition, disorders associated with emotional pain—especially depression and anxiety—also greatly complicate the clinician’s efforts to attain optimal outcomes for DPNP patients. This article reviews the high rate of comorbidity between DPNP and depression/anxiety with a focus on why this pattern of comorbidity exists and what can be done about it. To accomplish this, the many physiologic similarities between neuropathic pain and depression/anxiety are reviewed as a basis for better understanding how, and why, optimal treatment strategies use behavioral and pharmacologic modalities known to improve both physical pain and symptoms of depression and anxiety. We conclude by highlighting that screening, diagnosing, and optimally treating comorbid depression/anxiety not only improves quality of life, these but also positively impacts DPNP pain.


Diabetes mellitusDiabetic peripheral neuropathic pain (DPNP)Major depressionDepressive symptomsAnxietyPrevalenceInflammationPeripheral nervesCentral sensitizationKindlingSerotonin reuptake inhibitorsSerotonin-norepinephrine reuptake inhibitorsDuloxetinePregabalinα-2-δ ligandsTricyclic antidepressantsPsychotherapy, Cognitive behavior l therapyScreening instruments

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Rakesh Jain
    • 1
    • 6
  • Shailesh Jain
    • 2
  • Charles L. Raison
    • 3
  • Vladimir Maletic
    • 4
    • 5
  1. 1.Department of PsychiatryTexas Tech Health Sciences Center Medical School at Permian BasinMidlandUSA
  2. 2.Department of PsychiatryTexas Tech Health Sciences Center Medical School at Permian BasinMidlandUSA
  3. 3.Department of Psychiatry and Behavioral SciencesEmory University School of MedicineAtlantaUSA
  4. 4.Department of Neuropsychiatry and Behavioral SciencesUniversity of South Carolina School of MedicineColumbiaUSA
  5. 5.GreerUSA
  6. 6.Lake JacksonUSA