Article

Current Diabetes Reports

, Volume 11, Issue 3, pp 154-159

Gut Microbiota and the Pathogenesis of Insulin Resistance

  • Nathalie M. DelzenneAffiliated withLouvain Drug Research Institute, Metabolism and Nutrition Research Group, Université Catholique de LouvainLDRI/MNUT, UCL Email author 
  • , Patrice D. CaniAffiliated withLouvain Drug Research Institute, Metabolism and Nutrition Research Group, Université Catholique de Louvain

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Abstract

Several reviews recently explored how the gut microbiota was able to control host energy metabolism, and thereby the development of adiposity. In this review, we focused on the state of the art that supports a link between the gut microbiota composition and activity, and the management of glycemia associated with overweight and diabetes. Several microbial-derived compounds are related to disturbances of glucose homeostasis including the gram-negative–derived lipopolysaccharides. Some nutrients with prebiotic properties, which escape the digestion in the upper part of the gut, modify the composition of the gut microbiota in favor of bacteria that could play a beneficial role on glucose homeostasis, namely by modulating the endocrine function of the gut, and by reinforcing the gut barrier. Adequate intervention studies in diabetic patients are required to assess the relevance of those experimental data for human health.

Keywords

Gut microbiota Diabetes Prebiotics Inflammation Gut Lipopolysaccharides