Current Diabetes Reports

, Volume 10, Issue 1, pp 16-23

First online:

Multifactorial Intervention to Reduce Cardiovascular Events in Type 2 Diabetes

  • Swapnil N. RajpathakAffiliated withDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine
  • , Vikas AggarwalAffiliated withDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine
  • , Frank B. HuAffiliated withDepartments of Nutrition and Epidemiology, Harvard School of Public Health Email author 

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Type 2 diabetes is associated with a significantly increased risk of cardiovascular disease (CVD) morbidity and mortality. Although several clinical trials have evaluated the effects of interventions to reduce CVD risk in people with diabetes, such studies are primarily conducted to target individual risk factors such as hypertension, hyperglycemia, and dyslipidemia rather than using a multifactorial interventional approach. Existing clinical trial data suggest that intensive multifactorial interventions that target several important risk factors simultaneously result in a significantly greater risk reduction in CVD risk compared with single risk factor interventions. However, few studies have evaluated the efficacy and effectiveness of such interventions on CVD hard end points. A multidisciplinary team management of diabetes should focus on weight control, diet, physical activity, diabetes education, and adherence to pharmacotherapy. An individually tailored aggressive management program to reduce multiple CVD risk factors simultaneously has great potential to prevent CVD morbidity and mortality among patients with type 2 diabetes.


Diabetes Cardiovascular disease Multifactorial intervention Lifestyle intervention Nutrition Lipids Obesity Hypertension Hypoglycemia