, Volume 7, Issue 3, pp 235-241
Date: 05 Jul 2007

Glycotoxins in the diet promote diabetes and diabetic complications

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Oxidant stress underlies diabetes and diabetic complications, including cardiovascular, renal, and retinal disease. Advanced glycation end products (AGEs), or glycotoxins, are a significant contributor to oxidant stress in diabetes. The diet is a major, unrecognized source of AGEs. Importantly, reduction of dietary AGEs decreases circulating inflammatory markers in both diabetic patients and prediabetic patients and complications in animal models. This beneficial outcome requires only a 50% decrease in dietary AGEs, making this necessary intervention practical and inexpensive.