Current Diabetes Reports

, Volume 7, Issue 3, pp 235–241

Glycotoxins in the diet promote diabetes and diabetic complications


DOI: 10.1007/s11892-007-0037-z

Cite this article as:
Vlassara, H. & Striker, G. Curr Diab Rep (2007) 7: 235. doi:10.1007/s11892-007-0037-z


Oxidant stress underlies diabetes and diabetic complications, including cardiovascular, renal, and retinal disease. Advanced glycation end products (AGEs), or glycotoxins, are a significant contributor to oxidant stress in diabetes. The diet is a major, unrecognized source of AGEs. Importantly, reduction of dietary AGEs decreases circulating inflammatory markers in both diabetic patients and prediabetic patients and complications in animal models. This beneficial outcome requires only a 50% decrease in dietary AGEs, making this necessary intervention practical and inexpensive.

Copyright information

© Current Medicine Group LLC 2007

Authors and Affiliations

  1. 1.Division of Experimental Diabetes and Aging, Department of GeriatricsMount Sinai School of MedicineNew YorkUSA