Nonalcoholic fatty liver disease and cardiovascular disease risk
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- Schindhelm, R.K., Diamant, M. & Heine, R.J. Curr Diab Rep (2007) 7: 181. doi:10.1007/s11892-007-0030-6
Nonalcoholic fatty liver disease (NAFLD) is prevalent in people with the metabolic syndrome and type 2 diabetes. Evidence is now accumulating that NAFLD is associated with obesity and diabetes and may serve as a predictor of cardiovascular disease. Although at present, treatment of the individual risk factors pertinent to NAFLD is advocated, novel therapies are emerging that may target steatosis and/or inflammation, thus ameliorating the overall cardiovascular disease risk. Long-term outcome studies need to establish whether treatment of NAFLD (and in particular which therapy) will affect the long-term outcome.