Current Diabetes Reports

, Volume 7, Issue 2, pp 131–138

Insights on pathogenesis of type 2 diabetes from MODY genetics


DOI: 10.1007/s11892-007-0022-6

Cite this article as:
Weedon, M.N. & Frayling, T.M. Curr Diab Rep (2007) 7: 131. doi:10.1007/s11892-007-0022-6


Maturity-onset diabetes of the young (MODY) is a type of non-insulin-dependent diabetes mellitus caused by rare autosomal-dominant mutations. MODY genes play key biochemical roles in the pancreatic β cell; therefore, common variants of MODY genes are excellent candidate genes for type 2 diabetes. We review recent studies that suggest that common MODY gene variation contributes modestly to the heritability of type 2 diabetes.

Copyright information

© Current Medicine Group LLC 2007

Authors and Affiliations

  1. 1.Institute of Biomedical & Clinical Sciences, Peninsula College of Medicine & DentistryPeninsula Medical SchoolExeterUK