Insights on pathogenesis of type 2 diabetes from MODY genetics
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- Weedon, M.N. & Frayling, T.M. Curr Diab Rep (2007) 7: 131. doi:10.1007/s11892-007-0022-6
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Maturity-onset diabetes of the young (MODY) is a type of non-insulin-dependent diabetes mellitus caused by rare autosomal-dominant mutations. MODY genes play key biochemical roles in the pancreatic β cell; therefore, common variants of MODY genes are excellent candidate genes for type 2 diabetes. We review recent studies that suggest that common MODY gene variation contributes modestly to the heritability of type 2 diabetes.