Article

Current Diabetes Reports

, Volume 6, Issue 3, pp 182-187

Development of type 2 diabetes in children and adolescents

  • Ram Weiss
  • , Sara E. Taksali
  • , Sonia CaprioAffiliated withDepartment of Pediatrics, Yale University School of Medicine Email author 

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Abstract

Type 2 diabetes is emerging as a significant health problem in children and adolescents. The disease usually develops in obese insulin-resistant youth with a typical pattern of lipid partitioning characterized by increased lipid deposition in myocytes, the visceral compartment, and the liver. Unfavorable adipocytokine profiles, together with a state of low-grade inflammation, create an additional metabolic burden tightly coupled to other components of the metabolic syndrome. Insufficient β-cell compensation promotes altered glucose metabolism.