Development of type 2 diabetes in children and adolescents
- Cite this article as:
- Weiss, R., Taksali, S.E. & Caprio, S. Curr Diab Rep (2006) 6: 182. doi:10.1007/s11892-006-0032-9
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Type 2 diabetes is emerging as a significant health problem in children and adolescents. The disease usually develops in obese insulin-resistant youth with a typical pattern of lipid partitioning characterized by increased lipid deposition in myocytes, the visceral compartment, and the liver. Unfavorable adipocytokine profiles, together with a state of low-grade inflammation, create an additional metabolic burden tightly coupled to other components of the metabolic syndrome. Insufficient β-cell compensation promotes altered glucose metabolism.