Current Diabetes Reports

, Volume 5, Issue 2, pp 136–140

Adiponectin: An adipokine linking adipocytes and type 2 diabetes in humans

Authors

  • Kazuo Hara
    • Department of Metabolic Diseases, Graduate School of MedicineThe University of Tokyo
  • Toshimasa Yamauchi
    • Department of Metabolic Diseases, Graduate School of MedicineThe University of Tokyo
  • Takashi Kadowaki
    • Department of Metabolic Diseases, Graduate School of MedicineThe University of Tokyo
Article

DOI: 10.1007/s11892-005-0041-0

Cite this article as:
Hara, K., Yamauchi, T. & Kadowaki, T. Curr Diab Rep (2005) 5: 136. doi:10.1007/s11892-005-0041-0

Abstract

Adipocyte-derived adiponectin is an insulin-sensitizing and antiatherosclerotic hormone, and replenishment of adiponectin in animal models ameliorated insulin resistance and atherosclerosis. In humans, recent studies have demonstrated that adiponectin level is a good predictor of developing type 2 diabetes and coronary artery disease. Decreasing level of adiponectin is caused by the interaction between genetic factors, such as single nucleotide polymorphisms in the adiponectin gene, and environmental factors, such as high-fat diet. Agents that increase blood level of adiponectin or enhance the actions of adiponectin can be an ideal medicine for ameliorating insulin resistance and type 2 diabetes.

Copyright information

© Current Science Inc. 2005