Current Diabetes Reports

, Volume 5, Issue 3, pp 184–188

Is aggregated IAPP a cause of beta-cell failure in transplanted human pancreatic islets?

  • Per Westermark
  • Arne Andersson
  • Gunilla T. Westermark
Article

DOI: 10.1007/s11892-005-0007-2

Cite this article as:
Westermark, P., Andersson, A. & Westermark, G.T. Curr Diab Rep (2005) 5: 184. doi:10.1007/s11892-005-0007-2

Abstract

Aggregation of the â-cell product islet amyloid polypeptide (IAPP) is believed to be an important event in the development of the â-cell lesion in type 2 diabetes. Preamyloidotic oligomeric IAPP assemblies exert toxic effects on â cells that die, leading to reduced â-cell mass. Normal human islets, when isolated and cultured in vitro or transplanted into nude mice, also develop amyloid deposits, which are associated with increased â-cell death and reduced â-cell mass. The possible role of IAPP aggregation and amyloid formation in loss of islet transplant function should be taken into consideration and studied further.

Copyright information

© Current Science Inc 2005

Authors and Affiliations

  • Per Westermark
    • 1
  • Arne Andersson
  • Gunilla T. Westermark
  1. 1.Department of Biomedicine and Surgery, Cell BiologyLinköping UniversityLinköpingSweden

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