Is aggregated IAPP a cause of beta-cell failure in transplanted human pancreatic islets?
- Cite this article as:
- Westermark, P., Andersson, A. & Westermark, G.T. Curr Diab Rep (2005) 5: 184. doi:10.1007/s11892-005-0007-2
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Aggregation of the â-cell product islet amyloid polypeptide (IAPP) is believed to be an important event in the development of the â-cell lesion in type 2 diabetes. Preamyloidotic oligomeric IAPP assemblies exert toxic effects on â cells that die, leading to reduced â-cell mass. Normal human islets, when isolated and cultured in vitro or transplanted into nude mice, also develop amyloid deposits, which are associated with increased â-cell death and reduced â-cell mass. The possible role of IAPP aggregation and amyloid formation in loss of islet transplant function should be taken into consideration and studied further.