Oxidative stress and diabetic vascular complications
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
Vascular complications of diabetes represent the leading cause of morbidity and mortality in affected patients. Production of reactive oxygen species is increased in diabetic patients, especially in those with poor glycemic control. Reactive oxygen species affect vascular smooth muscle cell growth and migration, endothelial function, including abnormal endothelium-dependent relaxation and expression of a proinflammatory phenotype, and modification of the extracellular matrix. All of these events contribute to the development of diabetic microvascular and macrovascular complications, suggesting that the sources of reactive oxygen species and the signaling pathways that they modify may represent important therapeutic targets.
- The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulindependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group [no authors listed]. N Engl J Med 1993, 329:977-986.
- Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group [no authors listed]. Lancet 1998, 352:837-853.
- Griendling KK, FitzGerald GA: Oxidative stress and cardiovascular injury. Part II: animal and human studies. Circulation 2003, 108:2034–2040. CrossRef
- Hink U, Li H, Mollnau H, et al.: Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 2001, 88:E14-E22. Provides novel experimental evidence that PKC mediates superoxide production from uncoupled endothelial NO synthase and NAD(P)H oxidases.
- Ceriello A: New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy. Diabetes Care 2003, 26:1589–1596. Describes recent advances in our understanding of the role of oxidative stress in the development of diabetic complications. CrossRef
- Evans JL, Goldfine ID, Maddux BA, Grodsky GM: Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 2002, 23:599–622. CrossRef
- DeFronzo RA: Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes. Diabetes Rev 1997, 5:177–269.
- Brownlee M: Biochemistry and molecular cell biology of diabetic complications. Nature 2001, 414:813–820. CrossRef
- Sheetz MJ, King GL: Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA 2002, 288:2579–2588. CrossRef
- Bierman EL: George Lyman Duff Memorial Lecture. Atherogenesis in diabetes. Arterioscler Thromb 1992, 12:647–656.
- Bowie A, Owens D, Collins P, et al.: Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient? Atherosclerosis 1993, 102:63–67. CrossRef
- Ceriello A: Coagulation activation in diabetes mellitus: the role of hyperglycaemia and therapeutic prospects. Diabetologia 1993, 36:1119–1125. CrossRef
- Kiuchi K, Nejima J, Takano T, et al.: Increased serum concentrations of advanced glycation end products: a marker of coronary artery disease activity in type 2 diabetic patients. Heart 2001, 85:87–91. CrossRef
- Park L, Raman KG, Lee KJ, et al.: Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts. Nat Med 1998, 4:1025–1031. CrossRef
- Wautier MP, Chappey O, Corda S, et al.: Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE. Am J Physiol Endocrinol Metab 2001, 280:E685-E694.
- Taniyama Y, Griendling KK: Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension 2003, 42:1075–1081. CrossRef
- Koya D, Haneda M, Kikkawa R, King GL: d-alpha-tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C-diacylglycerol pathway. Biofactors 1998, 7:69–76.
- Mohamed AK, Bierhaus A, Schiekofer S, et al.: The role of oxidative stress and NF-kappaB activation in late diabetic complications. Biofactors 1999, 10:157–167.
- Ho FM, Liu SH, Liau CS, et al.: High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH(2)-terminal kinase and caspase-3. Circulation 2000, 101:2618–2624.
- Inoguchi T, Li P, Umeda F, et al.: High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes 2000, 49:1939–1945. CrossRef
- Ishii H, Jirousek MR, Koya D, et al.: Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 1996, 272:728–731. CrossRef
- Kakimoto M, Inoguchi T, Sonta T, et al.: Accumulation of 8- hydroxy-2’-deoxyguanosine and mitochondrial DNA deletion in kidney of diabetic rats. Diabetes 2002, 51:1588–1595. CrossRef
- Leinonen J, Lehtimaki T, Toyokuni S, et al.: New biomarker evidence of oxidative DNA damage in patients with non-insulin- dependent diabetes mellitus. FEBS Lett 1997, 417:150–152. CrossRef
- Williams SB, Cusco JA, Roddy MA, et al.: Impaired nitric oxidemediated vasodilation in patients with non-insulin-dependent diabetes mellitus. J Am Coll Cardiol 1996, 27:567–574. CrossRef
- Kim YK, Lee MS, Son SM, et al.: Vascular NADH oxidase is involved in impaired endothelium-dependent vasodilation in OLETF rats, a model of type 2 diabetes. Diabetes 2002, 51:522–527. Describes experiments clearly implicating the NAD(P)H oxidases as sources of ROS in type 2 diabetes. CrossRef
- Spitaler MM, Graier WF: Vascular targets of redox signalling in diabetes mellitus. Diabetologia 2002, 45:476–494. Excellent review of potential molecular targets of oxidative stress. CrossRef
- Garcia Soriano F, Virag L, Jagtap P, et al.: Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation. Nat Med 2001, 7:108–113. CrossRef
- Park KS, Kim JH, Kim MS, et al.: Effects of insulin and antioxidant on plasma 8-hydroxyguanine and tissue 8-hydroxydeoxyguanosine in streptozotocin-induced diabetic rats. Diabetes 2001, 50:2837–2841. CrossRef
- Suzuki LA, Poot M, Gerrity RG, Bornfeldt KE: Diabetes accelerates smooth muscle accumulation in lesions of atherosclerosis: lack of direct growth-promoting effects of high glucose levels. Diabetes 2001, 50:851–860. CrossRef
- Watson PA, Nesterova A, Burant CF, et al.: Diabetes-related changes in cAMP response element-binding protein content enhance smooth muscle cell proliferation and migration. J Biol Chem 2001, 276:46142–46150. CrossRef
- Fukumoto H, Naito Z, Asano G, Aramaki T: Immunohistochemical and morphometric evaluations of coronary atherosclerotic plaques associated with myocardial infarction and diabetes mellitus. J Atheroscler Thromb 1998, 5:29–35.
- Uemura S, Matsushita H, Li W, et al.: Diabetes mellitus enhances vascular matrix metalloproteinase activity: role of oxidative stress. Circ Res 2001, 88:1291–1298.
- Kashihara N, Watanabe Y, Makino H, et al.: Selective decreased de novo synthesis of glomerular proteoglycans under the influence of reactive oxygen species. Proc Natl Acad Sci U S A 1992, 89:6309–6313. CrossRef
- Etoh T, Inoguchi T, Kakimoto M, et al.: Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment. Diabetologia 2003, 46:1428–1437. CrossRef
- Ellis EA, Guberski DL, Somogyi-Mann M, Grant MB: Increased H2O2, vascular endothelial growth factor and receptors in the retina of the BBZ/Wor diabetic rat. Free Radic Biol Med 2000, 28:91–101. CrossRef
- Cameron NE, Cotter MA, Archibald V, et al.: Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats. Diabetologia 1994, 37:449–459. CrossRef
- Cameron NE, Cotter MA: Neurovascular dysfunction in diabetic rats. Potential contribution of autoxidation and free radicals examined using transition metal chelating agents. J Clin Invest1995, 96:1159–1163. CrossRef
- Cameron NE, Cotter MA: Effects of antioxidants on nerve and vascular dysfunction in experimental diabetes. Diabetes Res Clin Pract 1999, 45:137–146. CrossRef
- Abiko T, Abiko A, Clermont AC, et al.: Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes2003, 52:829–837. CrossRef
- Kunisaki M, Bursell SE, Clermont AC, et al.: Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway. Am J Physiol 1995, 269:E239-E246.
- Onozato ML, Tojo A, Goto A, et al.: Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB. Kidney Int 2002, 61:186–194. CrossRef
- Nassar T, Kadery B, Lotan C, et al.: Effects of the superoxide dismutase-mimetic compound tempol on endothelial dysfunction in streptozotocin-induced diabetic rats. Eur J Pharmacol 2002, 436:111–118. CrossRef
- Coppey LJ, Gellett JS, Davidson EP, et al.: Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve. Br J Pharmacol 2001, 134:21–29. CrossRef
- Cotter MA, Cameron NE, Keegan A, Dines KC: Effects of acetyl- and proprionyl-L-carnitine on peripheral nerve function and vascular supply in experimental diabetes. Metabolism 1995, 44:1209–1214. CrossRef
- Packer L, Kraemer K, Rimbach G: Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition 2001, 17:888–895. CrossRef
- Brenner BM, Cooper ME, de Zeeuw D, et al.: Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001, 345:861–869. Suggests a critical role for the renin-angiotensin system in diabetic nephropathy in patients with type 2 diabetes. CrossRef
- O'Driscoll G, Green D, Maiorana A, et al.: Improvement in endothelial function by angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol 1999, 33:1506–1511. CrossRef
- Arcaro G, Zenere BM, Saggiani F, et al.: ACE inhibitors improve endothelial function in type 1 diabetic patients with normal arterial pressure and microalbuminuria. Diabetes Care 1999, 22:1536–1542. CrossRef
- Vanhoutte PM, Boulanger CM, Mombouli JV: Endotheliumderived relaxing factors and converting enzyme inhibition. Am J Cardiol 1995, 76:3E-12E. CrossRef
- Beckman JA, Goldfine AB, Gordon MB, Creager MA: Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans. Circulation 2001, 103:1618–1623.
- Yusuf S, Dagenais G, Pogue J, et al.: Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000, 342:154–160. CrossRef
- Oxidative stress and diabetic vascular complications
Current Diabetes Reports
Volume 4, Issue 4 , pp 247-252
- Cover Date
- Print ISSN
- Online ISSN
- Current Medicine Group
- Additional Links