The genetics of adiponectin
- Cite this article as:
- Vasseur, F., Leprêtre, F., Lacquemant, C. et al. Curr Diab Rep (2003) 3: 151. doi:10.1007/s11892-003-0039-4
Adiponectin encoded by the APM1 gene is one of the adipocyte-expressed proteins that function in the homeostatic control of glucose, lipid, and energy metabolism. Its dysregulation has been suggested to be involved in disorders covering the metabolic X syndrome, such as insulin resistance, obesity, type 2 diabetes, and coronary artery disease. Recent data present evidence of a genetic modulation of the adiponectin level, and linkage of the 3q27 locus, where the APM 1 gene lies, with diabetes and features of the metabolic X syndrome playing a putative role of the APM 1 gene in this syndrome. In this article, we present an overview of the results available to date and discuss positive evidence for a role of genetic variants of the APM 1 gene and questions that genetic data raise.