, Volume 3, Issue 2, pp 151-158

The genetics of adiponectin

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Adiponectin encoded by the APM1 gene is one of the adipocyte-expressed proteins that function in the homeostatic control of glucose, lipid, and energy metabolism. Its dysregulation has been suggested to be involved in disorders covering the metabolic X syndrome, such as insulin resistance, obesity, type 2 diabetes, and coronary artery disease. Recent data present evidence of a genetic modulation of the adiponectin level, and linkage of the 3q27 locus, where the APM 1 gene lies, with diabetes and features of the metabolic X syndrome playing a putative role of the APM 1 gene in this syndrome. In this article, we present an overview of the results available to date and discuss positive evidence for a role of genetic variants of the APM 1 gene and questions that genetic data raise.