Current Diabetes Reports

, Volume 2, Issue 2, pp 135–140

Diabetes mellitus and other metabolic disturbances induced by atypical antipsychotic agents

  • David C. Henderson

DOI: 10.1007/s11892-002-0072-8

Cite this article as:
Henderson, D.C. Curr Diab Rep (2002) 2: 135. doi:10.1007/s11892-002-0072-8


Atypical antipsychotic agents offer significant advantages over older conventional antipsychotic agents. The reduction in antipsychotic drug-associated extrapyramidal symptoms and the potential reduced risk for tardive dyskinesia, compared to conventional drugs, are major advances in the treatment of psychotic patients. However, recent reports of hyperglycemia, new-onset diabetes mellitus, diabetic ketoacidosis, weight gain, and lipid abnormalities associated with atypical antipsychotic agents have emerged. A review of the recent literature and an approach to the evaluation of risk factors to aide in the safe use of atypical antipsychotic agents is presented.

Copyright information

© Current Science Inc 2002

Authors and Affiliations

  • David C. Henderson
    • 1
  1. 1.Freedom Trail ClinicMassachusetts General HospitalBostonUSA