Current Colorectal Cancer Reports

, Volume 10, Issue 1, pp 68–75

Molecular Predictors and Prognostic Markers in the Adjuvant Therapy for Colon Cancer

Personalized Medicine in Colorectal Cancer (CMS Rocha-Lima, Section Editor)

DOI: 10.1007/s11888-013-0199-9

Cite this article as:
Carcas, L.P. Curr Colorectal Cancer Rep (2014) 10: 68. doi:10.1007/s11888-013-0199-9
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Abstract

Colorectal cancer is a leading cause of cancer-related mortality in the USA. Although recent years have brought significant advances in treatment in the metastatic setting, the last major advance in the adjuvant setting was the addition of oxaliplatin to fluorouracil and leucovorin in the treatment of stage III disease. The benefit of adjuvant therapy in patients with stage II disease is not as clear. Prognostic and predictive markers help stratify patient risk and thereby indentify patients who may benefit from adjuvant therapy. The goal of this review is to help define the prognostic markers and molecular predictors that should be considered when attempting to personalize adjuvant therapy.

Keywords

Stage II colon cancerStage III colon cancerColorectal cancerAdjuvant therapyMolecular predictorPrognostic markerAgeSexBody mass indexGuanylyl cyclase CMicrosatellite instabilityGenome profileColoPrintOncotype DxPIK3CAIntratumor stromaFibroblast activation protein

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Sylvester Comprehensive Cancer CenterMiamiUSA