Current Colorectal Cancer Reports

, Volume 9, Issue 4, pp 372–379

The Association of Immune Cell Infiltration and Prognosis in Colorectal Cancer

  • Richard Palmqvist
  • Maria L. Wikberg
  • Agnes Ling
  • Sofia Edin
Immunotherapy of Malignancy (MA Morse, Section Editor)

DOI: 10.1007/s11888-013-0192-3

Cite this article as:
Palmqvist, R., Wikberg, M.L., Ling, A. et al. Curr Colorectal Cancer Rep (2013) 9: 372. doi:10.1007/s11888-013-0192-3

Abstract

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. The tumor microenvironment is of great biological importance in cancer development and progression and harbors several different immune cells representing both the innate and the adaptive immune response. These inflammatory cells may have both tumor-promoting and tumor-suppressing effects, and they have been shown to be of prognostic importance. This review summarizes the recent evidence regarding the prognostic significance of the host response to colorectal cancer.

Keywords

Colorectal cancer Inflammation Prognosis Immunity Metastatic Microsatellite instability 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Richard Palmqvist
    • 1
  • Maria L. Wikberg
    • 1
  • Agnes Ling
    • 1
  • Sofia Edin
    • 1
  1. 1.Department of Medical BiosciencesPathology, Umeå UniversityUmeåSweden

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