, Volume 9, Issue 4, pp 372-379
Date: 27 Oct 2013

The Association of Immune Cell Infiltration and Prognosis in Colorectal Cancer

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Abstract

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. The tumor microenvironment is of great biological importance in cancer development and progression and harbors several different immune cells representing both the innate and the adaptive immune response. These inflammatory cells may have both tumor-promoting and tumor-suppressing effects, and they have been shown to be of prognostic importance. This review summarizes the recent evidence regarding the prognostic significance of the host response to colorectal cancer.