Current Colorectal Cancer Reports

, Volume 9, Issue 3, pp 230–241

The Continuum of Care in Chemotherapy Approach to Metastatic Colorectal Cancer

Therapeutic Approaches to Metastatic Colorectal Cancers (E Díaz-Rubio, Section Editor)

DOI: 10.1007/s11888-013-0178-1

Cite this article as:
Jenab-Wolcott, J. & Giantonio, B. Curr Colorectal Cancer Rep (2013) 9: 230. doi:10.1007/s11888-013-0178-1
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Abstract

Colorectal cancer is a major public health problem and, despite recent advances in treatment, most patients with metastatic colorectal cancer (mCRC) will succumb to their disease. Yet, survival of patients with mCRC has markedly improved as the number of effective cytotoxic and novel targeted agents has grown. However, the best order and combination of these agents, and the optimum duration of treatment with the purpose of maximizing efficacy while minimizing toxicity are not fully established.

Keywords

Metastatic colorectal cancer mCRC Continuum of care Chemotherapy Anti-angiogenesis drugs Anti-EGFR drugs Targeted therapy Predictive markers Treatment breaks KRAS BRAF Clinical trials 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Regional Hematology and Oncology, P.A.NewarkUSA
  2. 2.Division of Hematology and OncologyHospital of University of PennsylvaniaPhiladelphiaUSA

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