Current Colorectal Cancer Reports

, Volume 8, Issue 1, pp 42–50

Clinical Implications and Quality Assurance of Molecular Testing for EGFR-Targeting Agents in Colorectal Cancer

  • Loredana Vecchione
  • Zenia Saridaki
  • Sabine Tejpar
Personalized Medicine in Colorectal Cancer (WA Messersmith, Section Editor)

DOI: 10.1007/s11888-011-0112-3

Cite this article as:
Vecchione, L., Saridaki, Z. & Tejpar, S. Curr Colorectal Cancer Rep (2012) 8: 42. doi:10.1007/s11888-011-0112-3

Abstract

The introduction in clinical practice of anti-epidermal growth factor receptor (EGFR) antibodies has improved the clinical outcome of metastatic colorectal cancer (mCRC) patients. Nevertheless, only 10% of mCRC tumors respond to these treatments, thus rendering the efforts made to maximize their therapeutic index justified. Although several biomarkers have been identified, we do not know yet how to administer these drugs in colorectal cancer patients in a “personalized–targeted manner.” With this review we will try to demonstrate that we need to go beyond the assumption of a binary relationship between one genetic event and response or resistance to anti-EGFR drugs and that several factors can influence the response to these agents. Therefore, the introduction in future approaches of a holistic genomic discovery plan instead of an individual and specific identification of alterations is needed.

Keywords

Metastatic colorectal cancerEGFR dependencyAnti-EGFR treatmentsCetuximabPanitumumabAnti-EGFR moAbsPersonalized cancer medicineColorectal cancer subgroupsMolecular subgroupsKRASBRAFPI3KCANRASPTENAmphiregulinEpiregulinHER2 amplificationGene moduleGene expression profileFcγRIIaFcγRIIΙaLet7Anti-EGFR sensitivityAnti-EGFR resistanceKRAS testing

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Loredana Vecchione
    • 1
    • 2
    • 3
  • Zenia Saridaki
    • 1
    • 2
  • Sabine Tejpar
    • 1
    • 2
  1. 1.Digestive Oncology UnitUniversity Hospital GasthuisbergLeuvenBelgium
  2. 2.Center for Human GeneticsKatholieke Universiteit LeuvenLeuvenBelgium
  3. 3.Division of Medical Oncology, Department of Experimental and Clinical Medicine and Surgery “F. Magrassi and A. Lanzara,”Second University of NaplesNaplesItaly