Date: 28 Dec 2011
Clinical Implications and Quality Assurance of Molecular Testing for EGFR-Targeting Agents in Colorectal Cancer
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The introduction in clinical practice of anti-epidermal growth factor receptor (EGFR) antibodies has improved the clinical outcome of metastatic colorectal cancer (mCRC) patients. Nevertheless, only 10% of mCRC tumors respond to these treatments, thus rendering the efforts made to maximize their therapeutic index justified. Although several biomarkers have been identified, we do not know yet how to administer these drugs in colorectal cancer patients in a “personalized–targeted manner.” With this review we will try to demonstrate that we need to go beyond the assumption of a binary relationship between one genetic event and response or resistance to anti-EGFR drugs and that several factors can influence the response to these agents. Therefore, the introduction in future approaches of a holistic genomic discovery plan instead of an individual and specific identification of alterations is needed.
Loredana Vecchione and Zenia Saridaki equally contributed to the manuscript writing.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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- Clinical Implications and Quality Assurance of Molecular Testing for EGFR-Targeting Agents in Colorectal Cancer
Current Colorectal Cancer Reports
Volume 8, Issue 1 , pp 42-50
- Cover Date
- Print ISSN
- Online ISSN
- Current Science Inc.
- Additional Links
- Metastatic colorectal cancer
- EGFR dependency
- Anti-EGFR treatments
- Anti-EGFR moAbs
- Personalized cancer medicine
- Colorectal cancer subgroups
- Molecular subgroups
- HER2 amplification
- Gene module
- Gene expression profile
- Anti-EGFR sensitivity
- Anti-EGFR resistance
- KRAS testing
- Industry Sectors
- Author Affiliations
- 1. Digestive Oncology Unit, University Hospital Gasthuisberg, Herestraat 49 bus 602, 3000, Leuven, Belgium
- 2. Center for Human Genetics, Katholieke Universiteit Leuven, Herestraat 49 bus 602, 3000, Leuven, Belgium
- 3. Division of Medical Oncology, Department of Experimental and Clinical Medicine and Surgery “F. Magrassi and A. Lanzara,”, Second University of Naples, via Pansini 5, 80131, Naples, Italy