Genetic Evaluation of Polyposis
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- Thomson, A.D., Kwok, R. & Weltman, M.D. Curr Colorectal Cancer Rep (2011) 7: 8. doi:10.1007/s11888-010-0073-y
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There is substantial ongoing work in elucidating the genetics of colorectal cancer (CRC). In this article, the state of the art and clinical application of CRC genetics for syndromic, familial, and sporadic carcinoma are discussed in detail. Clinical manifestations, genetics, diagnosis, and surveillance are discussed for major colorectal cancer syndromes. When a genetic polyposis syndrome is suspected, diagnosis should be confirmed. Careful consideration of screening for associated extracolonic conditions will lead to better patient outcomes. Genetic counseling and screening of family members is often indicated.