Management Strategies for Patients with KRAS Mutations
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- Leong, S., Eckhardt, S.G. & Messersmith, W.A. Curr Colorectal Cancer Rep (2010) 6: 199. doi:10.1007/s11888-010-0066-x
In an era of targeted therapies and personalized medicine, the search for predictive and prognostic biomarkers has reached the forefront in cancer research. Testing for KRAS mutation status in the treatment of colorectal cancer (CRC) has now become standard of care, especially for patients being considered for treatment with antibodies to the epidermal growth factor receptor (EGFR). Because metastatic CRC patients whose tumors harbor KRAS mutations do not respond to EGFR-targeting antibodies, their management is challenging. As our understanding of the role of KRAS mutations grows, new treatment strategies are being devised but are not yet ready for clinical use. In this review, we examine some of these potential strategies.